Sepsis News and Research

Latest Sepsis News and Research

FDA approves new labeling for psoriasis drug Raptiva

The U.S. Food and Drug Administration today announced labeling changes, including a Boxed Warning, to highlight the risks of life-threatening infections, including progressive multifocal leukoencephalopathy (PML), with the use of Raptiva (efalizumab). The labeling changes are based on the FDA's post-market surveillance.

19 Oct 2008

Probiotics unlikely to relieve eczema symptoms

Australian scientists say they have found no evidence that probiotics can relieve the irritating symptoms of eczema and what is more they suggest they may sometimes cause infections and gut problems.

13 Oct 2008

Statins may prevent miscarriages in antiphospholipid syndrome

Hospital for Special Surgery researchers have found that statins may be able to prevent miscarriages in women who are suffering from pregnancy complications caused by antiphospholipid syndrome (APS), according to a study in mice.

12 Oct 2008

Immune system protein accurate predictor of survival in pediatric septic shock

About 4,000 children in the United States die every year from uncontrolled infections of the body known as septic shock, and researchers are pushing the boundaries of molecular science to find new therapies that can stem the condition. But a simple measure of an immune system protein within 24 hours of being admitted to the hospital for septic shock can predict survival in children, yielding a powerful tool for diagnostics and clinical trials of new septic shock therapies, according to a research team led by Cincinnati Children's Hospital Medical Center in the Aug. 1 American Journal of Respiratory and Critical Care Medicine.

4 Aug 2008

Discovery of new anatomical path through which the brain and spleen communicate

In a major step in understanding how the nervous system and the immune system interact, scientists at The Feinstein Institute for Medical Research have identified a new anatomical path through which the brain and the spleen communicate.

21 Jul 2008

Suspect protein HMGB1 found to promote DNA repair, prevent cancer

An abundant chromosomal protein that binds to damaged DNA prevents cancer development by enhancing DNA repair, researchers at The University of Texas M. D. Anderson Cancer Center report online this week in the Proceedings of the National Academies of Science.

21 Jul 2008

Pitt awarded $2.5 million to model how the brain and immune system function in response to illness, infection

In an effort to promote the application of mathematics to medical treatment, researchers in the University of Pittsburgh's Department of Mathematics will undertake a $2.5 million project to create models of how the brain and immune system function and change over time in response to certain illnesses, infections, and treatment.

24 Jun 2008

New approach for assessing and managing patients with sepsis

Each year over a million people suffer from sepsis, a condition caused by an infection spreading through the body. If sepsis develops into severe sepsis then the death rate can rise to nearly 30 - 50%, equalling the number of deaths caused by a heart attack.

17 Jun 2008

Study identifies most costly adverse events in children's hospitals

A large study of health records from 38 American children's hospitals has measured adverse events that most increase length of stay and overall cost. The researchers say their findings provide useful targets for hospital programs aimed at preventing harm to young patients.

2 Jun 2008

Lack of dental care may have life-threatening implications

New research from the University of Bristol shows that admissions for the surgical treatment of dental abscess have doubled in the last ten years despite the fact that these serious infections are preventable with regular dental care.

29 May 2008

Ashwell receptor plays key role in reducing coagulation abnormalities during infection and sepsis

In research that solves the longest-standing mystery in glycobiology - a field that studies complex sugar chains called glycans - researchers at the University of California, San Diego School of Medicine have discovered that a molecule in the liver of all animals, called the Ashwell receptor, is critical in helping the body fight off the abnormal and lethal blood clotting caused by bacterial infection.

19 May 2008

Group B streptococcus has decreased among newborns, increased among adults

Group B streptococcus, a major cause of serious infections, declined about 25 percent among infants younger than 7 days from 1999 to 2005, but increased nearly 50 percent among persons 15 to 64 years old, according to a study in the May 7 issue of JAMA, the Journal of the American Medical Association.

6 May 2008

New discovery on role of vital protein that fights meningitus

A University of Leicester researcher has discovered how a protein in the blood - linked to defence against meningitis - plays a more vital role than previously understood in the body's immune defence system.

6 May 2008

Simple blood test screens for susceptibilty to meningococcal

A breakthrough in the fight against meningitis and meningococcal disease is apparently already proving to be a lifesaver.

20 Apr 2008

Acute kidney injury with sepsis

ICU patients with septic acute kidney injury (AKI) are generally sicker, have a higher burden of illness, a greater risk of mortality and longer stays in hospital than patients with non-septic AKI.

10 Apr 2008

Customized treatments for sepsis lower treatment time and reduce length of ICU stays

Using a blood test and a decision algorithm, rather than standard hospital protocols, to determine the appropriate length of antibiotic therapy in patients with severe sepsis or septic shock can reduce duration of treatments, shorten ICU stays, and lower hospital costs - all without adverse effects on patients, according to new research.

1 Mar 2008

Potential target to treat deadly bloodstream infections

Researchers at the University of Illinois at Chicago have discovered a possible target to treat bloodstream bacterial infections.

28 Feb 2008

Discovery of potential drug targets for sepsis

"We have identified a key connection of signaling pathways in the cascade of events leading to sepsis. This defines a crucial point where the immune system spirals out of control to cause severe sepsis and where there is an opportunity for therapeutic intervention," says Scripps Research Professor Wolfram Ruf, who led the research with his postdoctoral fellow Frank Niessen.

28 Feb 2008

Abbott receives approval for HUMIRA (Adalimumab) for polyarticular juvenile idiopathic arthritis

Abbott has announced that it has received U.S. Food and Drug Administration (FDA) approval to market HUMIRA (adalimumab) as a treatment to reduce signs and symptoms of moderately to severely active polyarticular juvenile idiopathic arthritis (JIA) in patients four years of age and older.

26 Feb 2008