Serotonin News and Research

Latest Serotonin News and Research

Combination therapy disables PI3K/Akt/mTOR pathway and induces apoptosis in carcinoid syndrome

Oncotarget published "Next-generation multimodality of nutrigenomic cancer therapy: sulforaphane in combination with acetazolamide actively target bronchial carcinoid cancer in disabling the PI3K/Akt/mTOR survival pathway and inducing apoptosis" which reported that microscopic imaging, immunocytochemistry, wound healing assay, caspase-cleaved cytokeratin 18 CytoDeath ELISA assay, immunofluorescence labeling assays for apoptosis, hypoxia, Western Blotting, Tunnel assay, measurement of 5-HT secretion by carbon fiber amperometry assay, quantitative methylation-specific PCR, morphologic changes, cell viability, apoptosis activity and the expression levels of phospho-Akt1, Akt1, HIF-1α, PI3K, p21, CAIX, 5-HT, phospho-mTOR, and mTOR in xenografts derived from typical H727 and atypical H720 BC cell lines.

28 Aug 2021

FDA-approved antiplatelet drug shows potential as new, low-cost heart failure therapy

Sarpogrelate, an antiplatelet medication, has potential as a new heart failure therapy and, according to researchers, could potentially decrease health care costs associated with cardiovascular disease, according to preliminary animal research presented at the American Heart Association's Basic Cardiovascular Sciences Scientific Sessions 2021.

23 Aug 2021

Research shines light on histamine as a potential key player in depression

Bodily inflammation dampens levels of a ‘feel-good molecule’ and antidepressants’ ability to boost them, according to new research in mice.

17 Aug 2021

Women say California insurer makes it too hard to get drug for postpartum depression

When Miriam McDonald decided she wanted to have another baby at age 44, her doctor told her she had a better chance of winning the lottery. So when she got pregnant right away, she and her husband were thrilled. But within three days of giving birth to their son, in September 2019, everything shifted.

28 Jul 2021

Investigational antipsychotic treatment offers sustained benefits for people with dementia-related psychosis

Evidence of the sustained benefits of an investigational antipsychotic treatment for people with dementia-related psychosis has been published.

22 Jul 2021

Gene therapy delivered into the brain may be safe, effective in treating rare neurological disorder

A new study published in Nature Communications suggests that gene therapy delivered into the brain may be safe and effective in treating aromatic L-amino acid decarboxylase (AADC) deficiency.

16 Jul 2021

Novel method of gene therapy promises to transform the treatment of rare genetic disorder

A novel method of gene therapy is helping children born with a rare genetic disorder called AADC deficiency that causes severe physical and developmental disabilities.

12 Jul 2021

Non-toxic derivative of tetanus neurotoxin may help treat depression, neurodegenerative diseases

Depression has been treated traditionally with inhibitors of serotonin reuptake in the central nervous system.

9 Jul 2021

Prenatal THC and CBD exposure impairs offspring's ability to respond to fluoxetine

Scientists at Indiana University have found that significant amounts of the two main components of cannabis, THC and CBD, enter the embryonic brain of mice in utero and impair the mice's ability as adults to respond to fluoxetine, a drug commonly used to treat anxiety and depression and known by the brand name Prozac.

1 Jul 2021

Declining sense of smell among older adults is more complex than previously believed

Contrary to what science once suggested, older people with a declining sense of smell do not have comprehensively dampened olfactory ability for odors in general - it simply depends upon the type of odor.

1 Jul 2021

New drug candidate may reduce anxiety-like behavior in mice

Anxiety, commonly termed as a feeling of fear, dread, and restlessness, is a perfectly normal reaction to stressful situations. However, a state of heightened anxiety, which is the reality for thousands of people who struggle to cope with these feelings, is called anxiety disorder.

29 Jun 2021

New analysis links distinct patterns of genetic mutations with OCD

In the first analysis of its kind, researchers at Columbia University Vagelos College of Physicians and Surgeons and several other institutions have linked distinct patterns of genetic mutations with obsessive-compulsive disorder (OCD) in humans.

28 Jun 2021

Study explores the potential role of gene polymorphisms in pathogenesis of prostate cancer

Oncotarget published "The presence of polymorphisms in genes controlling neurotransmitter metabolism and disease prognosis in patients with prostate cancer: a possible link with schizophrenia" reported that polymorphisms of neurotransmitter metabolism genes were studied in patients with prostate cancer (PC) characterized by either reduced or extended serum prostate-specific antigen doubling time corresponding to unfavorable and favorable disease prognosis respectively.

28 Jun 2021

Study delves into the link between smoking and suicidal behaviors

Psychiatry and Clinical Psychology residents Iván Echeverria, Miriam Cotaina and Antonio Jovani, from the Hospital Provincial of Castellón, doctor Ana Benito and doctor Gonzalo Haro from the TXP research group of the CEU UCH, and doctor Rafael Mora, have published the results of their latest research: a meta-analysis on suicide, the first cause of external death in Spain.

25 Jun 2021

Antidepressants taken during pregnancy do not increase risk for autism spectrum disorder

Women with depression and other mood disorders are generally advised to continue taking antidepressant medications during pregnancy.

24 Jun 2021

Study reviews natural drug candidates for potential treatment of COVID-19

A recent paper in the Saudi Journal of Biological Sciences seeks to open up new approaches by reviewing a list of compounds derived from plants and other natural sources, which have potential inhibitory activity against the coronavirus.

21 Jun 2021

Common antidepressant drugs help the immune system to attack tumors in mice

A class of drug called monoamine oxidase inhibitors is commonly prescribed to treat depression; the medications work by boosting levels of serotonin, the brain's "happiness hormone."

10 Jun 2021

Mast cell activation may underlie inflammation in severe COVID-19

A new preprint research paper posted to the medRxiv* server points to mast cells as major culprits in the etiology of severe and critical COVID-19. This could suggest suitable therapeutic and preventive interventions to reduce the morbidity and mortality of this viral illness.

3 Jun 2021

Research offers new hope for people affected by the microdeletion of chromosome 22

One person in 2000 suffers from a microdeletion of chromosome 22 that can lead to the development of psychotic disorders, such as schizophrenia, in adolescence.

1 Jun 2021

Study explains why it is difficult to withdraw from certain antidepressants

Researchers at the University of Illinois Chicago are a step closer to discovering why it is so difficult for people to withdraw from some antidepressant medications.

28 May 2021

Serotonin News and Research

Latest Serotonin News and Research

Combination therapy disables PI3K/Akt/mTOR pathway and induces apoptosis in carcinoid syndrome

FDA-approved antiplatelet drug shows potential as new, low-cost heart failure therapy

Research shines light on histamine as a potential key player in depression

Women say California insurer makes it too hard to get drug for postpartum depression

Investigational antipsychotic treatment offers sustained benefits for people with dementia-related psychosis

Gene therapy delivered into the brain may be safe, effective in treating rare neurological disorder

Novel method of gene therapy promises to transform the treatment of rare genetic disorder

Non-toxic derivative of tetanus neurotoxin may help treat depression, neurodegenerative diseases

Prenatal THC and CBD exposure impairs offspring's ability to respond to fluoxetine

Declining sense of smell among older adults is more complex than previously believed

New drug candidate may reduce anxiety-like behavior in mice

New analysis links distinct patterns of genetic mutations with OCD

Study explores the potential role of gene polymorphisms in pathogenesis of prostate cancer

Study delves into the link between smoking and suicidal behaviors

Antidepressants taken during pregnancy do not increase risk for autism spectrum disorder

Study reviews natural drug candidates for potential treatment of COVID-19

Common antidepressant drugs help the immune system to attack tumors in mice

Mast cell activation may underlie inflammation in severe COVID-19

Research offers new hope for people affected by the microdeletion of chromosome 22

Study explains why it is difficult to withdraw from certain antidepressants

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

Serotonin News and Research

Latest Serotonin News and Research

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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