T Cell News and Research

Latest T Cell News and Research

Single infusion of engineered T-cells achieves lasting asthma remission in mice

Researchers demostrate that durable asthma remission can be achieved with engineered and long-lived CAR T-cell treatment in mice.

31 May 2024

How tight binding between immune cells dictates T cell cancer-fighting ability

Immunotherapy, treatments that reinvigorate immune cells' anti-cancer activity or reprogram T cells to target cancer, has shown promise in treating leukemias but has not yet been realized in solid tumors.

30 May 2024

New paper reveals the broad potential of TNIK as a therapeutic target for some aging-related diseases

A new paper in Trends in Pharmacological Sciences from researchers at generative artificial intelligence (AI)- and robotics-powered clinical stage drug discovery company Insilico Medicine ("Insilico") and ETH Zurich reveals the broad potential of TNIK as a therapeutic target for some of the most pervasive aging-related diseases, including fibrosis, cancer, obesity, and Alzheimer's.

28 May 2024

New subset of T cells may enhance cancer immunotherapy

A team of cancer researchers, led by the University of Houston, has discovered a new subset of T cells that may improve the outcome for patients treated with T-cell therapies.

28 May 2024

Evolving treatment paradigms in multiple myeloma could improve patient outcomes

The treatment landscape for multiple myeloma, the second most common blood cancer, is shifting rapidly, with newly diagnosed patients increasingly being treated with a four-part drug combination that includes a new immunotherapy agent.

24 May 2024

Novel therapy reprograms immune cells, shrinks prostate and bladder cancers in animal study

A novel therapy that reprograms immune cells to promote antitumor activity helped shrink hard-to-treat prostate and bladder cancers in mice, according to research from the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy and Johns Hopkins Drug Discovery.

21 May 2024

ERS Genomics and IRBM sign CRISPR/Cas9 license agreement

ERS Genomics Limited (‘ERS’), the CRISPR licensing Company, and IRBM, a leader in the field of drug discovery, today announced a non-exclusive CRISPR/Cas9 license agreement. The agreement grants IRBM access to ERS’ CRISPR/Cas9 patent portfolio.

From ERS Genomics 21 May 2024

Comprehensive cost and utilization of commercial CAR-T therapy in pediatric B-ALL patients

A new editorial paper was published in Oncoscience (Volume 11) on April 25, 2024, entitled, "The price of hope: CAR-T therapy in pediatric leukemia."

17 May 2024

Immune checkpoint protein VISTA can directly turn off T-cells during immunotherapy, study finds

A Cleveland Clinic-led team of scientists and physicians have discovered that the immune checkpoint protein VISTA can directly turn off tumor-fighting T-cells during immunotherapy and resist treatment.

17 May 2024

Vaccine candidate spurs elusive type of broadly neutralizing HIV antibodies

An HIV vaccine candidate developed at the Duke Human Vaccine Institute triggered low levels of an elusive type of broadly neutralizing HIV antibodies among a small group of people enrolled in a 2019 clinical trial.

17 May 2024

Ketogenic diet a potential therapy for autism by reshaping gut bacteria and brain inflammation

Modified ketogenic diet modulates gut microbiome, inflammatory markers, and brain-related miRNAs in autistic children, correlating with improved behavioral symptoms. The diet increases beneficial gut bacteria and reduces inflammatory cytokines and BDNF levels.

9 May 2024

Bacterial fatty acid metabolite identified as key player in immune regulation

Gut microbiota or the population of microbial inhabitants in the intestine, plays a key role in digestion and maintenance of overall health.-

7 May 2024

Durable lymph-node expansion improves vaccine responses against tumors

Each one of us has around 600 lymph nodes (LNs) – small, bean-shaped organs that house various types of blood cells and filter lymph fluid – scattered throughout our bodies.

6 May 2024

New influenza vaccine strategies aim to enhance protection with T-cell responses

A recent review highlights the need for innovative influenza vaccines that combine T-cell and antibody responses to enhance protection across multiple strains and seasons.

6 May 2024

Liver cells effectively serve as immune checkpoint regulating anti-cancer immunity

Liver inflammation, a common side-effect of cancers elsewhere in the body, has long been associated with worse cancer outcomes and more recently associated with poor response to immunotherapy.

22 Apr 2024

Research highlights emergence of immune-evasive SARS-CoV-2 variants in immunocompromised patients

New research to be presented at next week's ESCMID Global Congress (formerly ECCMID) in Barcelona, Spain (27-30 April) highlights the risk of new immune-evasive SARS-CoV-2 variants emerging in immunocompromised patients.

18 Apr 2024

Metabolic health determines effectiveness of influenza vaccination

Metabolic health (normal blood pressure, blood sugar and cholesterol levels, among other factors) influences the effectiveness of influenza vaccinations. Vaccination is known to be less effective in people with obesity compared to those with a healthier body mass index (BMI), but St. Jude Children's Research Hospital scientists have found it is not obesity itself, but instead metabolic dysfunction, which makes the difference.

18 Apr 2024

New trials show promise for immune checkpoint blockers in early-stage lung cancer

A dendritic cell (DC) vaccine targeting patient-specific neoantigens to patients with resected non-small cell lung cancer (NSCLC).

18 Apr 2024

Study shows potential for universal flu vaccine with broad antibody response

Study discusses the potential of universal influenza vaccines, emphasizing the importance of antibody breadth and Fc receptor (FcR) effector functions in protecting against various influenza strains, including those with pandemic potential.

15 Apr 2024

Rethinking the germ theory: A balanced take on microbes and disease outcomes

Review explores the complexities of infectious disease outcomes through a balanced perspective, emphasizing the interplay between pathogenic microbes and host conditions, challenging the traditional germ-disease theory by proposing a more integrated view that considers both pathogen virulence and host immunity's impact on disease manifestation.

10 Apr 2024

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T Cell News and Research

Latest T Cell News and Research

Single infusion of engineered T-cells achieves lasting asthma remission in mice

How tight binding between immune cells dictates T cell cancer-fighting ability

New paper reveals the broad potential of TNIK as a therapeutic target for some aging-related diseases

New subset of T cells may enhance cancer immunotherapy

Evolving treatment paradigms in multiple myeloma could improve patient outcomes

Novel therapy reprograms immune cells, shrinks prostate and bladder cancers in animal study

ERS Genomics and IRBM sign CRISPR/Cas9 license agreement

Comprehensive cost and utilization of commercial CAR-T therapy in pediatric B-ALL patients

Immune checkpoint protein VISTA can directly turn off T-cells during immunotherapy, study finds

Vaccine candidate spurs elusive type of broadly neutralizing HIV antibodies

Ketogenic diet a potential therapy for autism by reshaping gut bacteria and brain inflammation

Bacterial fatty acid metabolite identified as key player in immune regulation

Durable lymph-node expansion improves vaccine responses against tumors

New influenza vaccine strategies aim to enhance protection with T-cell responses

Liver cells effectively serve as immune checkpoint regulating anti-cancer immunity

Research highlights emergence of immune-evasive SARS-CoV-2 variants in immunocompromised patients

Metabolic health determines effectiveness of influenza vaccination

New trials show promise for immune checkpoint blockers in early-stage lung cancer

Study shows potential for universal flu vaccine with broad antibody response

Rethinking the germ theory: A balanced take on microbes and disease outcomes

Immunology eBook

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

T Cell News and Research

Latest T Cell News and Research

Immunology eBook

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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