Life Science Articles

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The Thermal Inactivation of SARS-CoV-2

Viruses like SARS-CoV-2 are sensitive to thermal inactivation - temperature extremes that denature their constituent proteins and disable their function.

22 Mar 2021

Human Tumor Xenograft Models

In human tumor xenograft models, human tumor cells are transplanted into immunocompromised mice that do not reject human cells.

19 Mar 2021

What is Quantitative Systems Pharmacology (QSP) Modeling?

Quantitative systems pharmacology (QSP) is a field of biomedical research that aims to model the mechanisms behind disease progression.

18 Mar 2021

What are RNA Therapeutics?

RNA therapeutics utilize exogenously delivered RNA to instruct for the production of proteins, disrupt the production of proteins, or act as a targeting ligand.

17 Mar 2021

Primary vs Secondary Assays in Preclinical Testing

During the preclinical testing phase of drug discovery, compounds go through primary and secondary assays to determine potential for treatment of a disease.

12 Mar 2021

What is Preclinical Testing?

During the preclinical testing process of developing a compound to medicine, the compound in question must go through phases of testing.

11 Mar 2021

Exploring Preclinical Cancer Models

Researchers have developed a variety of cancer models that allow each aspect of a tumor to be analyzed at the in vitro and in vivo levels.

26 Feb 2021

The Ethics of Animal Models in Preclinical Testing

Animal testing is one of two routes usually selected for preclinical testing, the other being testing on human cell cultures in vitro.

25 Feb 2021

Preclinical Testing for Vaccines

Preclinical testing is required to demonstrate the safety of new vaccines before they can be tested on humans.

24 Feb 2021

What is Pharmacokinetics?

Pharmacokinetics is a field of study which helps scientists understand how a molecule behaves once in the body.

23 Feb 2021

What is Pharmacodynamics?

Pharmacodynamics, an essential concept within preclinical trials, studies the biological and physiological effects of drugs on an organism.

22 Feb 2021

Different Species of Animal Models in Preclinical Testing

A range of animal models can be used in preclinical testing, and certain species are favored in the research of particular disorders.

19 Feb 2021

What is Toxicity?

Drug toxicity studies are essential to assess the risk of any harmful side-effects, including the likelihood of carcinogenic effects and even death.

18 Feb 2021

What are Coenzymes?

Coenzymes are essential components of the many metabolic processes that sustain life on the cellular level including the citric acid cycle.

17 Feb 2021

In Vitro vs In Vivo Preclinical Studies

Before a drug candidate can be tested in humans, its safety and efficacy must be explored in in vitro or in vivo preclinical studies.

16 Feb 2021

The Importance of Pharmaceutical Packaging in Different Applications

Drugs may be distributed in a variety of primary and secondary pharmaceutical packaging, depending on the requirements of the drug itself and the intended user.

9 Feb 2021

What Standards Ensure the Quality of Pharmaceutical Packaging?

The strict regulations that control the quality of drugs extend to the packaging of said drugs, with governing bodies around the world setting standards.

9 Feb 2021

How is Sustainability Incorporated into Pharmaceutical Packaging?

Pharmaceutical packaging constitutes a small percentage of total generated waste, though it is still of significant concern to the World Health Organization.

9 Feb 2021