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Scientists discover how excess oxygen changes a handful of proteins in the cells

When it comes to oxygen, you can have too much of a good thing. Breathing air that contains higher levels of oxygen than the usual 21 percent found in Earth's atmosphere can cause organ damage, seizures, and even death in people and animals, particularly if it's in excess of the body's oxygen needs.

8 Mar 2023

Microglia partner with T cells to cause neurodegeneration, study shows

Nearly two dozen experimental therapies targeting the immune system are in clinical trials for Alzheimer's disease, a reflection of the growing recognition that immune processes play a key role in driving the brain damage that leads to confusion, memory loss and other debilitating symptoms.

8 Mar 2023

Scientists unearth a potential new target for treating age-related neurological diseases

Scientists from the Trinity Biomedical Sciences Institute (TBSI) have shed new light on aging processes in the brain.

8 Mar 2023

Connection between mitochondrial metabolite and activation of inflammatory response revealed

A new study shows for the first time a connection between a mitochondrial metabolite and the activation of an inflammatory response.

8 Mar 2023

Novel molecular mechanism responsible for common form of acquired hydrocephalus discovered

Mass General researchers have discovered a novel molecular mechanism responsible for the most common forms of acquired hydrocephalus, potentially opening the door to the first-ever nonsurgical treatment for a life-threatening disease that affects about a million Americans.

8 Mar 2023

Using tissue-embedded nanoelectronic devices to monitor the functional maturation of cardiomyocytes

Research in animal models has demonstrated that stem-cell derived heart tissues have promising potential for therapeutic applications to treat cardiac disease. But before such therapies are viable and safe for use in humans, scientists must first precisely understand on the cellular and molecular levels which factors are necessary for implanted stem-cell derived heart cells to properly grow and integrate in three dimensions within surrounding tissue.

8 Mar 2023

Detection and targeting of splicing deregulation reveal a potential strategy for pAML therapy

Pediatric acute myeloid leukemia or pAML is a childhood blood cancer, one that has proved confounding to clinicians and researchers, with a high relapse rate and relatively few identified genetic mutations (compared to the adult version) that might explain its cause.

8 Mar 2023

University of Utah and Tikkunlev partner to bring heart failure gene therapy innovation to the clinic

The University of Utah, one of the nation's leading research universities, and TikkunLev Therapeutics, a gene therapy company, have announced a new partnership to accelerate an innovative heart-failure gene therapy.

8 Mar 2023

Study identifies a potential new treatment approach for acute myeloid leukemia

A team of researchers has discovered a potential therapeutic that can synergize with existing drugs to more effectively kill certain leukemia cells.

8 Mar 2023

Discovery could lead to effective treatments for acute alcohol intoxication

A shot of a liver-produced hormone called FGF21 sobered up mice that had passed out from alcohol, allowing them to regain consciousness and coordination much faster than those that didn't receive this treatment, UT Southwestern researchers report in a new study.

8 Mar 2023

Novel culture system for effectively growing large numbers of blood stem cells in the lab

Hematopoietic stem cells (HSCs) are important immature blood cells in bone marrow that can be triggered to develop into any blood cell type.

8 Mar 2023

Study illuminates how the brain senses infection

A new study led by researchers at Harvard Medical School illuminates how the brain becomes aware that there is an infection in the body.

8 Mar 2023

Breakthrough drug works against all the main types of primary bone cancer

Researchers at the University of East Anglia have developed a new drug that works against all of the main types of primary bone cancer.

8 Mar 2023

Study unveils a key factor involved in the DNA damage response and repair

A research team, affiliated with UNIST has unveiled a key factor involved in the DNA damage response (DDR), homologous recombination (HR) and DNA interstrand crosslink (ICL) repair.

8 Mar 2023

Study may provide a new target for treatment of Alzheimer's disease

Reducing the methylation of a key messenger RNA can promote migration of macrophages into the brain and ameliorate symptoms of Alzheimer's disease in a mouse model, according to a new study publishing March 7th in the open access journal PLOS Biology by Rui Zhang of Air Force Medical University in Xian, Shaanxi, China.

7 Mar 2023

A shot of liver-produced hormone sobers up drunk mice

A hormone called fibroblast growth factor 21 (FGF21) protects mice against ethanol-induced loss of balance and righting reflex, according to a study publishing on March 7 in the journal Cell Metabolism.

7 Mar 2023

Johns Hopkins researchers partner with NASA to send heart “tissue-on-a-chip” specimens into space

Johns Hopkins Medicine researchers are collaborating with NASA to send human heart "tissue-on-a-chip" specimens into space as early as March.

7 Mar 2023

Newfound mechanism helps the heart to toggle between maintenance and energy-boost mode

Researchers at the Centre for Genomic Regulation in Barcelona have discovered a mechanism involving ribosomes which helps the heart toggle between a 'regular maintenance mode' for day-to-day function and an 'energy-boost mode' which aids recovery for high-demand situations including heart attacks.

7 Mar 2023

Research helps explain the metabolic differences of people living at high altitudes

Compared to those of us who live at sea level, the 2 million people worldwide who live above 4,500 meters (or 14,764 feet) of elevation-;about the height of Mount Rainier, Mount Whitney, and many Colorado and Alaska peaks-;have lower rates of metabolic diseases such as diabetes, coronary artery disease, hypercholesterolemia, and obesity.

7 Mar 2023

Study finds two substances capable of inhibiting proliferation of glioblastoma cells

Glioblastoma is a malignant tumor of the central nervous system (brain or spinal cord) and one of the deadliest types of cancer.

7 Mar 2023

Life Science News

Scientists discover how excess oxygen changes a handful of proteins in the cells

Microglia partner with T cells to cause neurodegeneration, study shows

Scientists unearth a potential new target for treating age-related neurological diseases

Connection between mitochondrial metabolite and activation of inflammatory response revealed

Novel molecular mechanism responsible for common form of acquired hydrocephalus discovered

Using tissue-embedded nanoelectronic devices to monitor the functional maturation of cardiomyocytes

Detection and targeting of splicing deregulation reveal a potential strategy for pAML therapy

University of Utah and Tikkunlev partner to bring heart failure gene therapy innovation to the clinic

Study identifies a potential new treatment approach for acute myeloid leukemia

Discovery could lead to effective treatments for acute alcohol intoxication

Novel culture system for effectively growing large numbers of blood stem cells in the lab

Study illuminates how the brain senses infection

Breakthrough drug works against all the main types of primary bone cancer

Study unveils a key factor involved in the DNA damage response and repair

Study may provide a new target for treatment of Alzheimer's disease

A shot of liver-produced hormone sobers up drunk mice

Johns Hopkins researchers partner with NASA to send heart “tissue-on-a-chip” specimens into space

Newfound mechanism helps the heart to toggle between maintenance and energy-boost mode

Research helps explain the metabolic differences of people living at high altitudes

Study finds two substances capable of inhibiting proliferation of glioblastoma cells

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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