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New research on DNA-repair enzyme could help enhance cancer drug development

Researchers from Rice University and St. Jude Children's Research Hospital in Memphis, Tennessee, took a close look at one of ways cells repair broken strands of DNA and discovered details that could help make a particular enzyme a promising target for precision cancer therapy.

6 Jan 2023

Collagen deposition at sites of intestinal injury stimulates cellular reprogramming

Most cells have a pretty normal life: they're born, they grow, they get old, and they die. But the Benjamin Buttons of the cellular world can go from old to young again in the right context.

6 Jan 2023

Cells live longer when they exchange metabolic products with each other

When cells exchange metabolic products with other cells, they live longer. This new finding comes from a research team at Charité – Universitätsmedizin Berlin, which made the discovery in a study using yeast cells.

6 Jan 2023

High affinity antibodies isolated to safely target Claudin 6-positive tumors

Integral Molecular, the industry leader in antibody discovery for membrane proteins, has published the targeting mechanism enabling best-in-class specificity of its Claudin 6 (CLDN6) antibody CTIM-76 being developed for cancer therapy with Context Therapeutics.

6 Jan 2023

Immotile cilia sense the direction of extracellular fluid during development to break left-right symmetry

Tiny, immobile cilia sense the direction of extracellular fluid during development to break left-right symmetry during early embryogenesis, researchers report in two independent studies that investigate this mechanism in mice embryos and zebrafish, respectively.

5 Jan 2023

Study offers novel insights into the elongation dynamics of eukaryotic cells

Life depends on the precise functioning of several proteins synthesized in cells by ribosomes. This diverse set of proteins, known as a proteome, is maintained by the robust translation elongation of amino acid sequences taking place in the ribosomes.

5 Jan 2023

Researchers reveal previously unknown properties of T cells

Certain T cells can secrete cytokines that are normally part of the innate immune system, as researchers from the Leibniz Institute for Natural Product Research and Infection Biology and an international research team discovered.

5 Jan 2023

Researchers elucidate the mechanism behind the formation of pores in mitochondrial membrane

Mitochondria are considered to be the power plants of cells and are essential for human metabolism. Dysfunction in 40 percent of mitochondrial proteins are associated with human diseases, which is why mitochondria also play an important role in medical research.

5 Jan 2023

New electrically conductive hydrogel scaffold supports neural cell differentiation

Brain-computer interfaces (BCIs) are a hot topic these days, with companies like Neuralink racing to create devices that connect humans' brains to machines via tiny implanted electrodes.

5 Jan 2023

Neural networks responsible for spatial perception change in a nonlinear manner, study shows

Young children sometimes believe that the moon is following them, or that they can reach out and touch it. It appears to be much closer than is proportional to its true distance.

5 Jan 2023

Researchers unravel how embryonic cells sense their mechanical environment

Building tissues and organs is one of the most complex and important tasks that cells must accomplish during embryogenesis.

5 Jan 2023

Comparison of genetic codes reveals how humans and other mammals lost their hair

Orangutans, mice, and horses are covered with it, but humans aren't. Why we have significantly less body hair than most other mammals has long remained a mystery.

5 Jan 2023

Irish study demonstrates a genetic effect on the response to obesity treatments

Collaborative research between University of Galway and Brunel University London has found that patients with severe and complicated obesity respond differently to a dietary weight loss program based on their genes.

5 Jan 2023

Genotype-first approach uncovers new relationships between genes and clinical conditions

National Institutes of Health researchers have published an assessment of 13 studies that took a genotype-first approach to patient care.

5 Jan 2023

Researchers develop a new approach to better understand the biology of polycystic kidney disease

A research team supported by the National Institutes of Health has developed a new approach to better understand the biology of polycystic kidney disease (PKD), an often-life-threatening genetic disorder that affects millions worldwide.

5 Jan 2023

Cilia act as sensors to establish body left-right asymmetry during embryogenesis

Although the human body is externally symmetric across the left-right axis, there are remarkable left-right asymmetries in the shape and positioning of most internal organs including the heart, lungs, liver, stomach, and brain.

5 Jan 2023

Insilico Medicine launches a 6th generation Intelligent Robotics Drug Discovery Laboratory

Insilico Medicine, a clinical stage, end-to-end artificial intelligence (AI)-driven drug discovery company, held the launch ceremony for Life Star – a 6th generation Intelligent Robotics Drug Discovery Laboratory – in Suzhou BioBAY Industrial Park on Dec. 29.

5 Jan 2023

How does mindful attention change brain function to support self-regulation?

Researchers observed that mindful attention promoted control of brain network dynamics.

5 Jan 2023

PhoreMost and Boehringer Ingelheim enter multi-project drug discovery collaboration

PhoreMost Limited, the UK-based biopharmaceutical company dedicated to drugging ‘undruggable’ disease targets, today announced it has entered into a multi-project drug discovery collaboration with Boehringer Ingelheim, one of the world-leading pharmaceutical companies developing innovative therapies for diseases with unsatisfactory treatments.

From PhoreMost 5 Jan 2023

Evolutionary advantage of jumping genes in a fungus discovered

A fungus that infects salamanders contains multiple copies of the same "jumping genes", scientists have discovered.

4 Jan 2023

Life Science News

New research on DNA-repair enzyme could help enhance cancer drug development

Collagen deposition at sites of intestinal injury stimulates cellular reprogramming

Cells live longer when they exchange metabolic products with each other

High affinity antibodies isolated to safely target Claudin 6-positive tumors

Immotile cilia sense the direction of extracellular fluid during development to break left-right symmetry

Study offers novel insights into the elongation dynamics of eukaryotic cells

Researchers reveal previously unknown properties of T cells

Researchers elucidate the mechanism behind the formation of pores in mitochondrial membrane

New electrically conductive hydrogel scaffold supports neural cell differentiation

Neural networks responsible for spatial perception change in a nonlinear manner, study shows

Researchers unravel how embryonic cells sense their mechanical environment

Comparison of genetic codes reveals how humans and other mammals lost their hair

Irish study demonstrates a genetic effect on the response to obesity treatments

Genotype-first approach uncovers new relationships between genes and clinical conditions

Researchers develop a new approach to better understand the biology of polycystic kidney disease

Cilia act as sensors to establish body left-right asymmetry during embryogenesis

Insilico Medicine launches a 6th generation Intelligent Robotics Drug Discovery Laboratory

How does mindful attention change brain function to support self-regulation?

PhoreMost and Boehringer Ingelheim enter multi-project drug discovery collaboration

Evolutionary advantage of jumping genes in a fungus discovered

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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