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Study reveals why some germinal centers persist for months rather than weeks

If B cells are the munitions factories of the immune system, manufacturing antibodies to neutralize harmful pathogens, then the tiny biological structures known as germinal centers are its weapons-development facilities.

23 Dec 2022

High ammonia levels lead to fewer T cells and immunotherapy resistance in colorectal cancer

High levels of ammonia in tumors lead to fewer T cells and immunotherapy resistance in mouse models of colorectal cancer, new findings from the University of Michigan Rogel Cancer Center revealed.

23 Dec 2022

Researchers develop a lateral flow test to reliably identify and quantify allergens in foods

A team from the Universitat Politècnica de València, the Universitat de València, and the Centro de Investigación Biomédica en Red sobre Enfermedades Raras has developed a lateral flow test that identifies and quantifies the level of allergens reliably in food with the help of a smartphone.

23 Dec 2022

New technology achieves 99.7% purity in sorting target cells in real-time

Researchers from the Qingdao Institute of Bioenergy and Bioprocess Technology of the Chinese Academy of Sciences have proposed a new technology, called optical tweezer-assisted pool-screening and single-cell isolation (OPSI) system, which achieves 99.7% purity of sorting target cells, with all done in real-time.

23 Dec 2022

Study reveals protective role of CRTC1 in stopping people from overeating high-calorie foods

High-calorie foods-;high in fat, oil, and sugar-;can taste good but often cause overeating, leading to obesity and major health problems. But what stimulates the brain to cause overeating?

23 Dec 2022

Researchers present a new strategy for self-adjuvanting vaccine development

This new article publication from Acta Pharmaceutica Sinica B, discusses a fully synthetic Tn-based three-component cancer vaccine using covalently linked TLR4 ligand MPLA and iNKT cell agonist KRN-7000 as built-in adjuvant effectively protects mice from tumor development.

23 Dec 2022

Cellular models based on reprogrammed human cells could boost development of efficient therapies

Studies on diseases that affect the human brain are usually based on animal models which cannot reproduce the complexity of human neuropathies.

22 Dec 2022

Researchers identify a new pathogenic mechanism for diabetes onset in MODY3

In order to treat patients with diabetes in the best possible way it is necessary to understand the disease mechanism. MODY type 3 (MODY3) is a monogenic hereditary form of diabetes, that is caused by a genetic defect in the HNF1A gene.

22 Dec 2022

Specialized MRI sensor can detect light deep within tissues

Using a specialized MRI sensor, MIT researchers have shown that they can detect light deep within tissues such as the brain.

22 Dec 2022

UC San Diego researchers rewrite the textbook on gene regulation

A fundamental principle of molecular biology governs how proteins are made within the cell, which happens in two stages called transcription and translation.

22 Dec 2022

DISCO-MS technology enables the study of diseases at their earliest stages

How can you trace a single diseased cell in an intact brain or a human heart? The search resembles looking for a needle in a haystack.

22 Dec 2022

Simple laser irradiation speeds up the detection of very small amounts of proteins

Protein detection based on antigen–antibody reaction is vital in early diagnosis of a wide range of diseases. How to effectively detect proteins, however, has frequently bedeviled researchers.

22 Dec 2022

NIH scientists use patient stem cells and 3D bioprinting to produce eye tissue

Scientists used patient stem cells and 3D bioprinting to produce eye tissue that will advance understanding of the mechanisms of blinding diseases.

22 Dec 2022

Decade-long search in one-celled, fresh water dwelling organism solves puzzle involved in gene regulation

After an intrepid, decade-long search, Johns Hopkins Medicine scientists say they have found a new role for a pair of enzymes that regulate genome function and, when missing or mutated, are linked to diseases such as brain tumors, blood cancers and Kleefstra syndrome -; a rare genetic, neurocognitive disorder.

22 Dec 2022

Research serves as a platform to identify therapeutic drugs for schizophrenia

Inflammation and overactivation of the immune system in the brain can cause loss of synapses and the death of neurons, leading to neurodegenerative and psychiatric diseases.

22 Dec 2022

3D neutron tomography reveals water diffusion across the bone material

What keeps bones able to remodel themselves and stay healthy? A team from Charité Berlin has discovered clues to the key function of non-collagen protein compounds and how they help bone cells react to external load.

22 Dec 2022

Study increases understanding of the genetic architecture of dementia risk in African ancestry populations

In the largest-ever genetic study of dementia in people of African ancestry, VA researchers identified several genetic risks different from those seen in people of European ancestry.

22 Dec 2022

Researchers unravel how one of the crucial early steps on the path of life could have happened

One-hundred fifty years ago, Charles Darwin speculated that life likely originated in a warm little pond. There, Darwin supposed, chemical reactions and the odd lightning strike might have led to chains of amino acids that, over time, became more and more complex until the beginnings of life emerged.

21 Dec 2022

Recapitulating early stages of the human body plan in a dish

Although Michelangelo's masterpiece David captured the magnificence of the human body - how this exquisite body plan is exactly established during human development has puzzled scientists for more than a century.

21 Dec 2022

Mutations responsible for common inherited heart condition corrected using CRISPR-Cas9 therapy

Using the CRISPR-Cas9 gene editing system, UT Southwestern researchers corrected mutations responsible for a common inherited heart condition called dilated cardiomyopathy (DCM) in human cells and a mouse model of the disease.

21 Dec 2022

Life Science News

Study reveals why some germinal centers persist for months rather than weeks

High ammonia levels lead to fewer T cells and immunotherapy resistance in colorectal cancer

Researchers develop a lateral flow test to reliably identify and quantify allergens in foods

New technology achieves 99.7% purity in sorting target cells in real-time

Study reveals protective role of CRTC1 in stopping people from overeating high-calorie foods

Researchers present a new strategy for self-adjuvanting vaccine development

Cellular models based on reprogrammed human cells could boost development of efficient therapies

Researchers identify a new pathogenic mechanism for diabetes onset in MODY3

Specialized MRI sensor can detect light deep within tissues

UC San Diego researchers rewrite the textbook on gene regulation

DISCO-MS technology enables the study of diseases at their earliest stages

Simple laser irradiation speeds up the detection of very small amounts of proteins

NIH scientists use patient stem cells and 3D bioprinting to produce eye tissue

Decade-long search in one-celled, fresh water dwelling organism solves puzzle involved in gene regulation

Research serves as a platform to identify therapeutic drugs for schizophrenia

3D neutron tomography reveals water diffusion across the bone material

Study increases understanding of the genetic architecture of dementia risk in African ancestry populations

Researchers unravel how one of the crucial early steps on the path of life could have happened

Recapitulating early stages of the human body plan in a dish

Mutations responsible for common inherited heart condition corrected using CRISPR-Cas9 therapy

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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