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Cell adhesion and starvation found to be key drivers of pattern formation in keratinocytes

Cell-cell adhesion-induced patterning in keratinocytes can be explained by just starvation and strong adhesion, Hokkaido University researchers find.

12 Aug 2024

Researchers develop new method to study critical type of protein modification process

Human proteins undergo a variety of chemical modifications following their synthesis. These modifications regulate their structure, function, and stability.

12 Aug 2024

New research identifies key protein complex in cellular quality control

Anyone who's tried to neatly gather a fitted sheet can tell you: folding is hard. Get it wrong with your laundry and the result can be a crumpled, wrinkled mess of fabric, but when folding fails among the approximately 7,000 proteins with an origami-like complexity that regulate essential cellular functions, the result can lead to one of a multitude of serious diseases ranging from emphysema and cystic fibrosis to Alzheimer's disease.

12 Aug 2024

New genomic predictors of relapse in childhood B-cell acute lymphoblastic leukemia uncovered

Scientists from St. Jude Children's Research Hospital, Seattle Children's and the Children's Oncology Group (COG) have identified novel genetic variations that influence relapse risk in children with standard risk B-cell acute lymphoblastic leukemia (SR B-ALL), the most common childhood cancer.

12 Aug 2024

Cell nuclei found to control tissue architecture in eye and brain development

In work conducted both at UC Santa Barbara and the Physics of Life Excellence Cluster of TU Dresden, biophysicist Otger Campàs and his research group have found that cell nuclei control the architecture and mechanics of eye and brain tissues during embryonic development.

12 Aug 2024

New breast cell atlas sheds light on genetic ancestry's role in cancer development

Researchers at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center have completed the most extensive mapping of healthy breast cells to date.

12 Aug 2024

Howard Hughes Medical Institute announces $500 million to support AI-driven projects in life sciences

The Howard Hughes Medical Institute today announced AI@HHMI, a $500 million investment over the next 10 years to support artificial intelligence-driven projects in the life sciences.

12 Aug 2024

Study reveals how light-activated macrophages increase their appetite for cancer cells

The body has a veritable army constantly on guard to keep us safe from microscopic threats from infections to cancer.

12 Aug 2024

New histone tag discovery offers hope for myelin repair in neurodegenerative diseases

In a groundbreaking study, researchers with the Advanced Science Research Center at the CUNY Graduate Center (CUNY ASRC) have identified a distinct histone tag in adult oligodendrocyte progenitor cells (OPCs) that may pave the way for innovative therapies targeting myelin repair, a critical target for several neurodegenerative and psychiatric disorders, including multiple sclerosis, Alzheimer's disease, and schizophrenia.

12 Aug 2024

Can odors help fight infection? Nematode research suggests so

Researchers from the University of California, Berkeley, used the nematode model Caenorhabditis elegans to determine whether the olfactory nervous system could non-autonomously control the mitochondrial unfolded protein response in response to cellular stress.

12 Aug 2024

New proteomic clock predicts biological age and major health risks across diverse populations

Study developed a proteomic age clock using plasma proteins to accurately predict biological age and associated health risks, offering a robust tool for forecasting age-related diseases and mortality.

11 Aug 2024

Mechanisms of tissue shape transformation revealed through fruit fly wing development

A key question that remains in biology and biophysics is how three-dimensional tissue shapes emerge during animal development.

9 Aug 2024

New insights into retrotransposon-derived DNA zip codes in myeloma cells

A new editorial was published in Oncoscience (Volume 11) on July 13, 2024, entitled, "Unveiling retrotransposon-derived DNA zip code for myeloma cell internalization."

9 Aug 2024

Breakthrough in the synthesis of fungal bioactive compounds for therapeutic applications

The natural world is rich in chemical compounds with remarkable medicinal properties. A notable example is penicillin, discovered by chance from the Penicillium mold.

9 Aug 2024

Controllable chiral switching in double-helical foldamers for advanced molecular systems

The deoxyribonucleic acid or DNA, the molecular system that carries the genetic information of living organisms, can transcribe and amplify information using its two helical strands.

9 Aug 2024

DeepPBS: A geometric AI model for accurate prediction of protein-DNA binding specificity

A new artificial intelligence model developed by USC researchers and published in Nature Methods can predict how different proteins may bind to DNA with accuracy across different types of protein, a technological advance that promises to reduce the time required to develop new drugs and other medical treatments.

9 Aug 2024

Machine learning revolutionizes gene delivery

Gene therapy could potentially cure genetic diseases but it remains a challenge to package and deliver new genes to specific cells safely and effectively. Existing methods of engineering one of the most commonly used gene-delivery vehicles, adeno-associated viruses (AAV), are often slow and inefficient.

9 Aug 2024

Lensless fluorescence detection system provides highly sensitive water quality assessment

Researchers have shown that a fluorescence detection system that doesn't contain any lenses can provide highly sensitive detection of deadly microorganisms in drinking water. With further development, the new approach could provide a low-cost and easy-to-use way to monitor water quality in resource-limited settings such as developing countries or areas affected by disasters. It could also be useful when water safety results are needed quickly, such as for swimming events, a concern highlighted during the Paris Olympics.

9 Aug 2024

Breakthrough study uncovers TIP60’s role in DNA access and disease mechanisms

To transcribe the information contained in our genes or to repair the dozens of breaks that occur daily in our DNA, our enzymes must be able to directly access the DNA to perform their functions.

9 Aug 2024

Autism and ADHD linked to neighborhood conditions

Autistic youth who were born in underserved neighborhoods are more likely to have greater attention deficit hyperactivity disorder (ADHD) symptoms than those born in communities with more resources. This is one finding of a new study led by researchers at the UC Davis MIND Institute.

9 Aug 2024

Life Science News

Cell adhesion and starvation found to be key drivers of pattern formation in keratinocytes

Researchers develop new method to study critical type of protein modification process

New research identifies key protein complex in cellular quality control

New genomic predictors of relapse in childhood B-cell acute lymphoblastic leukemia uncovered

Cell nuclei found to control tissue architecture in eye and brain development

New breast cell atlas sheds light on genetic ancestry's role in cancer development

Howard Hughes Medical Institute announces $500 million to support AI-driven projects in life sciences

Study reveals how light-activated macrophages increase their appetite for cancer cells

New histone tag discovery offers hope for myelin repair in neurodegenerative diseases

Can odors help fight infection? Nematode research suggests so

New proteomic clock predicts biological age and major health risks across diverse populations

Mechanisms of tissue shape transformation revealed through fruit fly wing development

New insights into retrotransposon-derived DNA zip codes in myeloma cells

Breakthrough in the synthesis of fungal bioactive compounds for therapeutic applications

Controllable chiral switching in double-helical foldamers for advanced molecular systems

DeepPBS: A geometric AI model for accurate prediction of protein-DNA binding specificity

Machine learning revolutionizes gene delivery

Lensless fluorescence detection system provides highly sensitive water quality assessment

Breakthrough study uncovers TIP60’s role in DNA access and disease mechanisms

Autism and ADHD linked to neighborhood conditions

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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