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New mechanism that regulates dietary lipid processing by the intestine revealed

The maintenance of a balanced lipid homeostasis is critical for our health. While consumption of excessive amounts of fatty foods contributes to metabolic diseases such as obesity and atherosclerosis, fat is an indispensable component of our diet.

20 Dec 2023

TMDU researchers develop novel method to identify protein-protein binding interfaces

Proteins are building blocks of our bodies, but they do not work solo. They form partners to facilitate in different biological processes that keep us going.

20 Dec 2023

First new antibiotic class in decades discovered using explainable AI platform

Scientists have discovered one of the first new classes of antibiotics identified in the past 60 years, and the first discovered leveraging an AI-powered platform built around explainable deep learning.

20 Dec 2023

New statistical technique improves disease prediction for people of African descent

A team of scientists from Icahn School of Medicine at Mount Sinai has developed a groundbreaking statistical technique, "BridgePRS," to enhance disease prediction in people of non-European ancestry, particularly those of African descent.

20 Dec 2023

Study reveals cytoglobin's pivotal role in cilia movement and organ positioning during development

Study reveals that cytoglobin (cygb2) plays a crucial role in regulating cilia motility and organ laterality during development, highlighting its importance in NO signaling and cilia function.

19 Dec 2023

Embryonic immune sensor could key to creating patient-derived blood stem cells

A microbial sensor that helps identify and fight bacterial infections also plays a key role in the development of blood stem cells, valuable new insight in the effort to create patient-derived blood stem cells that could eliminate the need for bone marrow transplants.

19 Dec 2023

Novel adaptations and functions of human LINE-1 revealed by structural analysis and inhibition

Martin Taylor, MD, PhD, a physician investigator in the Department of Pathology at Massachusetts General Hospital and an instructor in Pathology at Harvard Medical School, is the lead corresponding author of a new study in Nature, Structural Analysis and Inhibition of Human LINE-1 ORF2 Protein Reveals Novel Adaptations and Functions.

19 Dec 2023

Sirtuin 6: A potential savior for aging cartilage and osteoarthritis

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 23, entitled, "Sirtuin 6 activation rescues the age-related decline in DNA damage repair in primary human chondrocytes."

19 Dec 2023

A novel stem cell solution for preventing ischemia-induced amputations

Across the United States, about 2 million people are living with an amputation and another 185,000 amputations occur every year, according to the Amputee Coalition, a Washington DC-based support group.

19 Dec 2023

Study reveals hidden inactive form of p38a protein

p38a protein, a key enzyme in the regulation of various cellular functions, plays a crucial role in some diseases, including cancer, chronic inflammation, and neurodegenerative conditions.

19 Dec 2023

Groundbreaking genome-editing technique holds promise for treating Charcot–Marie–Tooth disease

Scientific advances in the last century have changed our world significantly. For example, the world of genetics has opened doors to a myriad of possibilities: augmented human capabilities, cures for diseases, and even changes to the course of evolution.

19 Dec 2023

Patient-specific muscle models pave way for personalized neuromuscular therapies

Scientists have so far identified around 800 different neuromuscular diseases. These conditions are caused by problems in the way muscle cells, motor neurons and peripheral cells interact.

19 Dec 2023

Kyoto scientists map double whammy gene clusters for anxiety disorders

Anxiety disorders (ADs) affect more than 280 million people worldwide, making them one of the most common mental health conditions. ADs have a genetic basis as seen from inheritance in families, and people with one subtype of AD tend to have another subtype, suggesting a shared genetic basis.

19 Dec 2023

From Neanderthals to now: Tracing the evolution of human sleep cycles

Researchers examined the differences in circadian biology between the ancestors of modern humans and the archaic hominins such as Denisovans and Neanderthals and the contribution of archaic introgression in human chronotypes by using genomes to trace chronotype evolution from archaic hominins to modern-day humans.

19 Dec 2023

Bridging ideas to IND: Nona Biosciences' year of impact in biotechnology

Amidst a backdrop of industry-wide hurdles like inflation, talent scarcities, and stringent regulatory landscapes, Nona Biosciences is showing great promise as an emerging global leader in biotechnology.

From Nona BioSciences 19 Dec 2023

Key Charpentier/Doudna CRISPR patent upheld by Japanese Patent Office

Patent JP6692856 upheld for second time in response to invalidation challenge.

19 Dec 2023

Mice with humanized immune systems test new cancer therapeutic approach that blindfolds immune cells to the body’s self-recognition system

Researchers investigated the anticancer effects of drugs targeting human tumor-associated macrophages (TAMs) in vivo. In humanized murine models, they tested the effectiveness of an antibody to human signal regulatory protein alpha (SIRPα) for cancer immunotherapy.

19 Dec 2023

Life Science News

New mechanism that regulates dietary lipid processing by the intestine revealed

TMDU researchers develop novel method to identify protein-protein binding interfaces

First new antibiotic class in decades discovered using explainable AI platform

New statistical technique improves disease prediction for people of African descent

Study reveals cytoglobin's pivotal role in cilia movement and organ positioning during development

Embryonic immune sensor could key to creating patient-derived blood stem cells

Novel adaptations and functions of human LINE-1 revealed by structural analysis and inhibition

Sirtuin 6: A potential savior for aging cartilage and osteoarthritis

A novel stem cell solution for preventing ischemia-induced amputations

Study reveals hidden inactive form of p38a protein

Groundbreaking genome-editing technique holds promise for treating Charcot–Marie–Tooth disease

Patient-specific muscle models pave way for personalized neuromuscular therapies

Kyoto scientists map double whammy gene clusters for anxiety disorders

From Neanderthals to now: Tracing the evolution of human sleep cycles

Bridging ideas to IND: Nona Biosciences' year of impact in biotechnology

Key Charpentier/Doudna CRISPR patent upheld by Japanese Patent Office

Mice with humanized immune systems test new cancer therapeutic approach that blindfolds immune cells to the body’s self-recognition system

“Forever chemicals” could contribute to cancer metastasis in living organisms

Leaky gut linked to depressive disorders: New insights into microbiota-induced epigenetic changes

Study reveals altered time perception in early Alzheimer's stages, offering potential early diagnostic marker

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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