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Discovery of potential drug targets for sepsis

"We have identified a key connection of signaling pathways in the cascade of events leading to sepsis. This defines a crucial point where the immune system spirals out of control to cause severe sepsis and where there is an opportunity for therapeutic intervention," says Scripps Research Professor Wolfram Ruf, who led the research with his postdoctoral fellow Frank Niessen.

28 Feb 2008

Stopping bird flu at the border

Several strains of the bird flu virus that raged across southern China were blocked from entering Thailand and Vietnam, UC Irvine researchers have discovered.

28 Feb 2008

Scientists look at 'syringe' assembly in plague bacteria

Bacteria that cause the bubonic plague avoid death in our bodies by injecting our cells with immune evasion proteins.

28 Feb 2008

Scientists devise approach that stops HIV at earliest stage of infection

Their study, which appears this week in the online Early Edition of the Proceedings of the National Academy of Sciences (PNAS), may re-energize attempts to create a preventive/therapeutic vaccine against HIV, say the authors.

28 Feb 2008

Restricting insulin doses increases mortality risk in women with type 1 diabetes

A new study led by researchers at the Joslin Diabetes Center has found that women with type 1 diabetes who reported taking less insulin than prescribed had a three-fold increased risk of death and higher rates of disease complications than those who did not skip needed insulin shots.

28 Feb 2008

Discovery of family of genes linked to the development of liver cancer

An interdisciplinary team of researchers at Stony Brook University Medical Center has identified a family of genes linked to the development of liver cancer.

28 Feb 2008

New vaccine technology decreases E. coli in beef cattle

Despite millions of dollars spent on food safety research over the last 10 years, ground beef recalls due to E. coli O157:H7 were higher in 2007 than in 2006, according to researchers from Kansas State University and West Texas A&M University. E. coli O157:H7 has been linked to foodborne illnesses in humans after consuming contaminated beef and produce.

28 Feb 2008

Research leading to tools for managing bovine respiratory disease complex

Bovine respiratory disease complex has multiple causes. It's sometimes hard to classify and predict. It also costs the beef industry more than any other disease -- an estimated $690 million in 2006, according to one report.

28 Feb 2008

Overweight Hispanic children shown to have vascular inflammation

Overweight Hispanic children with normal blood glucose (sugar) levels showed elevated markers for blood vessel inflammation that may predispose them to developing both type 2 diabetes and cardiovascular disease, says a new study led by researchers from the Joslin Diabetes Center.

28 Feb 2008

New radiology center puts research scanners in hospital

Whether it's needed to track the activity of a drug, the growth of a tumor, or the progress of a medical disorder, high-tech imaging equipment often is an essential component of advanced clinical research.

28 Feb 2008

Diltiazem reduces cocaine cravings in a rat model

Researchers from Boston University School of Medicine and Harvard Medical School have found that diltiazem, a drug used in the treatment of high blood pressure, reduces cocaine cravings in a rat model.

28 Feb 2008

New drug trial to target hereditary cancers

Cancer Research UK scientists at Newcastle University are starting the first UK trial of a new drug which targets the 'Achilles' heel' in hereditary forms of both breast and ovarian cancer.

28 Feb 2008

New drug trial to target hereditary cancers

Cancer Research UK scientists at Newcastle University are starting the first UK trial of a new drug which targets the 'Achilles' heel' in hereditary forms of both breast and ovarian cancer.

28 Feb 2008

New blood biomarker accurately predicts spread of prostate cancer to regional lymph nodes

Researchers report finding a new blood biomarker that enables close to 98 percent accuracy in predicting the spread of prostate cancer to regional lymph nodes.

28 Feb 2008

Neurons use chemical 'chords' to shape signaling

Researchers have discovered that neurons can use two different neurotransmitters that target the same receptor on a receiving neuron to shape the transmission of a nerve impulse.

28 Feb 2008

Forest Laboratories to develop and distribute the novel beta blocker Bystolic (nebivolol)

Mylan Inc. has announced that it and Forest Laboratories Holdings, Ltd., a wholly owned subsidiary of Forest Laboratories, Inc. have amended their January 2006 agreement to commercialize, develop and distribute the novel beta blocker Bystolic (nebivolol), which is currently approved in the United States for the treatment of hypertension.

28 Feb 2008