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PEA-15 protein points to potential targeted approach for ovarian cancer

A protein known to inhibit the growth of ovarian cancer works in part by forcing cancer cells to eat themselves until they die, researchers at The University of Texas M. D. Anderson Cancer Center report in the Nov. 15 issue of Cancer Research .

16 Nov 2008

Pelvic girdle syndrome linked to diabetes

Diabetes appears to be linked with an increased risk of pelvic girdle syndrome. This is shown in a new study from the Norwegian Institute of Public Health and Akershus University Hospital.

16 Nov 2008

Plastic surgeons warn of malnutrition in body contouring patients

Identifying malnutrition before surgery in massive weight loss patients seeking body contouring will significantly decrease surgical complications, accelerate wound healing, improve scar quality and boost patient energy levels, according to a study in the December issue of Plastic and Reconstructive Surgery ®, the official medical journal of the American Society of Plastic Surgeons (ASPS).

16 Nov 2008

Previously unknown regulatory step during HIV replication provides potential new target for HIV/AIDS therapy

A previously unknown regulatory step during human immunodeficiency (HIV) replication provides a potentially valuable new target for HIV/AIDS therapy, report researchers at the Salk Institute for Biological Studies and the University of Wisconsin, Madison.

16 Nov 2008

No evidence supporting the use of vitamin E and C in the prevention of cancer

The Physicians' Health Study II is a large-scale, long-term, randomized clinical trial that included 14,641 physicians who were at least 50 years old at enrollment.

16 Nov 2008

Combination of carboplatin and paclitaxel with bevacizumab and cetuximab proves safe for lung cancer treatment

The four drug-combination of carboplatin and paclitaxel, with the targeted therapies bevacizumab (Avastin) and cetuximab (Erbitux), is safe and may improve survival for patients with advanced lung cancer, according to a cooperative group study led by The University of Texas M. D. Anderson Cancer Center.

16 Nov 2008

New clue for cellular damage in Huntington's disease

"Huntington's disease presents an ideal vantage point to study neurodegenerative disease, because we know the misfolded protein that's responsible," says Martin Duennwald, formerly a postdoctoral researcher in the lab of Whitehead Member Susan Lindquist.

16 Nov 2008

Community-based physical activity interventions found to be cost-effective

Community-based physical activity interventions designed to promote more active lifestyles among adults are cost-effective in reducing heart disease, stroke, colorectal and breast cancers, and type 2 diabetes, according to a study by the Centers for Disease Control and Prevention, with support from the Robert Wood Johnson Foundation.

16 Nov 2008

Microbial population of raw milk found to be more complex than previously thought

Raw milk is illegal in many countries as it can be contaminated with potentially harmful microbes.

16 Nov 2008

Negative thinking may play a bigger role in heart failure than previously thought

Researchers at the University of Kentucky found that patients who had negative thinking patterns, such as thoughts about not being able to justify their own existence, were at higher risk for developing depression.

16 Nov 2008

Nanoparticles may alter cell structure and pose health risks

Nanoparticles that are one milliard of a metre in size are widely used, for example, in cosmetics and food packaging materials.

16 Nov 2008

Discovery of key contributor to Alzheimer's disease process

Walter J. Lukiw, PhD, Associate Professor of Neuroscience and Ophthalmology at LSU Health Sciences Center New Orleans, is the lead author of a paper identifying, for the first time, a specific function of a fragment of ribonucleic acid (RNA), once thought to be no more than a byproduct, in regulating inflammation and the development of Alzheimer's disease.

16 Nov 2008

Aspirin lowers PSA levels

The use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) is significantly associated with lower PSA levels, especially among men with prostate cancer, say researchers at Vanderbilt University.

16 Nov 2008

In child care, relationships with caregivers key to children's stress levels

How children are affected by out-of-home care depends not only on the qualities of their teacher and the classroom, but also on the nature of the children's relationship with their caregivers.

16 Nov 2008

Vigabatrin offers hope for treating relapse to methamphetamine abuse

A new study at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory suggests that vigabatrin (a.k.a. gamma vinyl-GABA, or GVG) blocks drug-seeking behavior in animals previously trained to associate methamphetamine with a particular environment.

16 Nov 2008

How household bleach kills bacteria

Despite the fact that household bleach is commonly used as a disinfectant, exactly how it works to fight bacteria remained an open question.

16 Nov 2008

Higher levels of blood phosphate may be a previously unidentified and modifiable cardiovascular risk factor

Healthy adults with higher levels of phosphate in the blood are more likely to have increased levels of calcium in the coronary arteries-a key indicator of atherosclerosis and future cardiovascular disease risk, reports a study in the February 2009 issue of the Journal of the American Society of Nephrology (JASN).

16 Nov 2008

No clear evidence that depression screening improves cardiovascular patients' health

Results of a new study call into question recent clinical guidelines issued by leading cardiovascular groups, including the American Heart Association, which recommend patients with cardiovascular disease be screened for signs of depression and treated accordingly.

16 Nov 2008

Healthy life expectancy in Europe

Although life expectancy is constantly growing in the countries of the EU, living longer isn't always the same as living well, and knowing to what age someone will live in good health remains a different question altogether.

16 Nov 2008

Potential new therapeutic targets for rejuvenating the aged immune system

In the November 15th issue of G&D, Dr. Kenneth Dorshkind and colleagues at the David Geffen School of Medicine (UCLA) have identified two genes - p16(Ink4a) and Arf - that sensitize lymphoid progenitor cells to the effects of aging, and confer resistance to leukemogenesis.

16 Nov 2008