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Gene expression in meningiomas may vary by hormone receptor status

An association between hormones and meningioma has long been postulated, but the specific nature of this relationship has remained unclear.

4 Feb 2008

Breastfeeding now safer for infants of HIV-infected mothers

An antiretroviral drug already in widespread use in the developing world to prevent the transmission of HIV from infected mothers to their newborns during childbirth has also been found to substantially cut the risk of subsequent HIV transmission during breast-feeding.

4 Feb 2008

New discovery, immune cells confront viruses just inside of the lymph node

Vaccines have led to many of the world's greatest public health triumphs, but many deadly viruses, such as HIV, still elude the best efforts of scientists to develop effective vaccines against them. An improved understanding of how the immune system operates during a viral infection is critical to designing successful anti-virus vaccines.

4 Feb 2008

Certain genetic variations protect against depression triggered by childhood stress

Certain variations in a gene that helps regulate response to stress tend to protect adults who were abused in childhood from developing depression, according to new research funded by the National Institute of Mental Health (NIMH), part of the National Institutes of Health.

4 Feb 2008

Less waste in the synthesis of anti-inflammatory drugs

Dr Francesca Paradisi of the Centre for Synthesis and Chemical Biology (CSCB) at University College Dublin, and Professor Daria Giacomini and co-workers at the University of Bologna, Italy, have developed a highly efficient enzyme-driven process which could be applied to the synthesis of drugs such as Ibuprofen, avoiding the 50% waste of the undesired byproduct generated by current processes.

4 Feb 2008

New Parkinson's disease research points to serotonin

For most people with Parkinson's disease, the only relief from the tremors, rigidity and impaired movement associated with the progressive loss of their motor skills is a drug called L-DOPA. But as the disease progresses, L-DOPA can cause prominent side effects that counteract its effectiveness.

4 Feb 2008

Massachusetts health care subsidy program cost, enrollment could double over three years

Commonwealth Care, Massachusetts' subsidized health insurance program, is expected to double in enrollment and cost by June 2011, which "would far outstrip the original plans" for the program "largely because state officials underestimated the number of uninsured residents," the Boston Globe reports.

4 Feb 2008

Budget request from President Bush to increase spending for SCHIP by $19.7B over five years

President Bush on Monday will release a $3 trillion fiscal year 2009 budget request that would significantly reduce or eliminate spending for dozens of health and other programs but would significantly increase spending for SCHIP, the New York Times reports.

4 Feb 2008

Florida Governor proposes $70B budget; includes $132M in cuts to Medicaid

Florida Gov. Charlie Crist (R) on Thursday unveiled a $70 billion state budget for fiscal year 2009 that would reduce spending on health care by $132 million and that includes new initiatives to expand health coverage, the Orlando Sentinel reports (Kennedy/Deslatte, Orlando Sentinel, 2/1). Crist proposed reducing Medicaid reimbursements for HMOs by $60 million (Follick, Sarasota Herald-Tribune, 2/1).

4 Feb 2008

USA Today examines possible reasons for five-year low of FDA drug approval rate

USA Today on Monday examined how some pharmaceutical industry analysts cite "more cautious regulators and less innovation by drug makers" as reasons for the low rate of new drug approvals in 2007 (Schmit, USA Today, 2/4).

4 Feb 2008

Researchers examine immune cells where HIV can lie dormant, possible treatments

Researchers have determined how HIV is able to lie dormant in certain immune system cells and prevent the cells from self-destructing, according to a study published Thursday online in the journal Retrovirology, the AP/Google.com reports.

4 Feb 2008

Researchers examine effect of male circumcision on female partners

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4 Feb 2008

Democrats to seek changes, boosted funding during PEPFAR reauthorization debate

Some Congressional Democrats have proposed removing abstinence program spending requirements and a mandatory pledge against commercial sex work in the upcoming reauthorization of the President's Emergency Plan for AIDS Relief, the AP/Yahoo! News reports (Abrams, AP/Yahoo! News, 2/2). The lawmakers also are hoping to allow "reproductive health groups to have broader access to U.S. money," according to CQ Today.

4 Feb 2008

PNG Coalition Against HIV/AIDS to implement programs in businesses nationwide

The Papua New Guinea Business Coalition Against HIV/AIDS plans to work with businesses in the country to implement the coalition's policy on HIV/AIDS in the workplace, Rod Mitchell, CEO of the coalition, said recently, the Papua New Guinea Post-Courier reports.

4 Feb 2008

Hillary Clinton discusses enforcement mechanism for health insurance mandate

Democratic presidential candidate Sen. Hillary Rodham Clinton (N.Y.) on Sunday during an appearance on ABC's "This Week with George Stephanopoulos" discussed her proposal to require all U.S. residents to obtain health insurance and "inched closer ... to explaining how she would enforce" the requirement but "declined to specify -- as she has throughout the campaign -- how she would penalize those who refuse," the New York Times reports.

4 Feb 2008

Scientists recreate rhinovirus infection in mice - hope of new asthma treatments

Scientists have been able to recreate rhinovirus infection, which is behind most common colds, in a small animal for the first time.

4 Feb 2008

Scientists identify protein's crucial role in resistance to breast cancer treatment

Scientists at the Breakthrough Breast Cancer Research Centre at The Institute of Cancer Research in London have identified how some breast cancers may become resistant to hormone treatments like tamoxifen.

4 Feb 2008

Video games activate reward regions of brain in men more than women

Allan Reiss, MD, and his colleagues have a pretty good idea why your husband or boyfriend can't put down the Halo 3. In a first-of-its-kind imaging study, the Stanford University School of Medicine researchers have shown that the part of the brain that generates rewarding feelings is more activated in men than women during video-game play.

4 Feb 2008

FDA approves only once-daily inhaled corticosteroid for children

Schering-Plough Corporation has announced that the U.S. Food and Drug Administration (FDA) has approved ASMANEX TWISTHALER 110 mcg (mometasone furoate inhalation powder) for the maintenance treatment of asthma as a preventive therapy in patients 4 to 11 years of age.

4 Feb 2008

Isocitric acid from fermentation of sunflower oil - a new building block for pharma?

The citric acid cycle, one of the most important metabolic processes in our bodies, was formulated in 1937. Since then, all of the intermediates have been produced in multigram quantities - with one exception, (2 R,3S)-isocitric acid.

4 Feb 2008