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Collaborative effort by FDA and EMEA expected to yield additional safety data when assessing new drugs

In the first use of a framework allowing submission of a single application to the two agencies, the Food and Drug Administration (FDA) and the European Medicines Agency (EMEA) worked together to allow drug companies to submit the results of seven new tests that evaluate kidney damage during animal studies of new drugs. The tests measure the levels of seven key proteins or "biomarkers" found in urine that can provide additional information about drug-induced damage to kidney cells, also known as renal toxicity.

15 Jun 2008

Nanoparticles trigger built-in cell-death signal to overcome drug resistance

One of the most vexing problems in treating cancer is the propensity of tumors to develop resistance to a wide range of anticancer drugs. Over 70 percent of ovarian cancer patients, for example, have drug-resistant tumors at the time of their initial diagnosis, and virtually all patients who relapse have drug-resistant tumors.

15 Jun 2008

High-content screening as a universal tool for fingerprinting of vytotoxicity of nanoparticles

As researchers develop an ever-expanding toolkit of nanoparticles for use as drug and imaging agent delivery vehicles, there is a growing need to understand how a given nanoparticle's physical and chemical properties affect biological activity and toxicity.

15 Jun 2008

Nanoparticle delivers antisense agent to tumors

A multifunctional drug delivery system consisting of a lipid-based nanoparticle, a standard anticancer drug, and a short nucleic acid designed to augment the activity of that drug has demonstrated the ability to treat drug-resistant tumor cells.

15 Jun 2008

Cancer-detecting nanoparticles

Magnetic resonance imaging (MRI) can be a doctor's best friend for detecting a tumor in the body without resorting to surgery. MRI scans use pulses of magnetic waves and gauge the return signals to identify different types of tissue in the body, distinguishing bone from muscle, fluids from solids, and so on.

15 Jun 2008

Human tumor nanoparticles induce apoptosis of pancreatic cancer cells

Using nanoparticles made from pieces of tumor cells, investigators from Aix-Marseille University in Marseille, France, have developed a new type of anticancer agent that appears to stop tumor cell growth and proliferation.

15 Jun 2008

Targeted quantum rods probe blood-brain barrier

One of the chief difficulties in treating brain tumors involves getting potential tumor-killing drugs across the blood-brain barrier and into the brain.

15 Jun 2008

Discovery of mechanism that prevents cells from transforming into cancer cells

MRC scientists have discovered a mechanism that prevents cells from transforming into cancer cells. As cells age they enter a state called senescence, a kind of suspended animation that allows a cell to keep functioning but prevents it from changing. This state can also be triggered by what's called an 'insult' to the cell, for example a signal from a cancer-initiating gene.

15 Jun 2008

New technique provides greater understanding of how drugs get in and out of cells in our bodies

A team led by female scientists at the Universities of Bristol and Cambridge has developed an exciting new technique which may lead to a greater understanding of how drugs get in and out of the cells in our bodies. The method identifies the structures that guard the entrance and exits to cells.

15 Jun 2008

Scientists identify molecular trick that may explain part of Salmonella's fierceness

Salmonella is serving up a surprise not only for tomato lovers around the country but also for scientists who study the rod-shaped bacterium that causes misery for millions of people.

15 Jun 2008

UT Southwestern investigators test groundbreaking depression research in real-world setting

UT Southwestern Medical Center psychiatry researchers have taken what they learned from their groundbreaking research on treating depression and are applying it to real-world clinical settings.

15 Jun 2008

UT Southwestern surgeons complete the first Lap-Band weight-loss surgery in Texas using single incision as entry point

UT Southwestern Medical Center surgeons have completed the first single-incision Lap-Band weight-loss surgery in Texas.

15 Jun 2008

Industry supports international melanoma research

Provectus Pharmaceuticals and the Australia and New Zealand Melanoma Trials Group (ANZMTG) have joined forces to advance cutting edge melanoma research at the University of Sydney.

15 Jun 2008

Rural, unmarried women at higher risk for depression

Mayo Clinic research suggests unmarried women living in rural areas have lower self-rated health status than their married counterparts.

11 Jun 2008

Australian Government oddly excludes AMA again on health plans - AMA negative about plans to ease GP shortage

Government plans to expand the roles of health professionals such as nurses, pharmacists, physiotherapists and dieticians, to help address the shortage of doctors, has not surprisingly evoked a negative response from the Australian Medical Association (AMA).

11 Jun 2008

AHF to Dr. Fauci and the CDC: "show us the AIDS numbers"

AIDS Healthcare Foundation (AHF) is calling for the immediate release of the Centers for Disease Control and Prevention's (CDC) latest HIV incidence numbers, after Dr. Anthony Fauci, Director of the National Institute of Allergy and Infectious Diseases (NIAID) referred to them while in attendance at the United Nations' 2008 High Level Meeting on AIDS in New York this week. The US largest AIDS organization and operator of free AIDS treatment clinics in the U.S., Africa, Latin America/Caribbean and Asia, also called for massive scale-up of HIV testing throughout the nation.

11 Jun 2008

Age-adjusted death rates in U.S. down sharply in 2006

Age-adjusted death rates in the United States dropped significantly between 2005 and 2006 and life expectancy hit another record high, according to preliminary death statistics released today by CDC's National Center for Health Statistics.

11 Jun 2008

Smoking and obesity linked to hearing loss

One of the largest studies into the risk factors for age-related hearing loss has found that smoking and body mass index (BMI) are two of the main culprits whereas alcohol has a protective effect, but high levels of work noise remain the biggest risk.

11 Jun 2008

Simple steps can help reduce your risk of contracting potentially deadly superbug

With beach-season looming, the fitness bug is motivating Chicagoans to fill area gyms in droves, all hoping to buff up before the warm-weather season of fun gets into full swing.

11 Jun 2008

Researchers find gamma-secretase modulators being tested for Alzheimer’s work in unexpected and beneficial ways

Researchers at Mayo Clinic, with their national and international collaborators, have discovered how a class of agents now in testing to treat Alzheimer's disease work, and say they may open up an avenue of drug discovery for this disease and others.

11 Jun 2008

Medical News

Collaborative effort by FDA and EMEA expected to yield additional safety data when assessing new drugs

Nanoparticles trigger built-in cell-death signal to overcome drug resistance

High-content screening as a universal tool for fingerprinting of vytotoxicity of nanoparticles

Nanoparticle delivers antisense agent to tumors

Cancer-detecting nanoparticles

Human tumor nanoparticles induce apoptosis of pancreatic cancer cells

Targeted quantum rods probe blood-brain barrier

Discovery of mechanism that prevents cells from transforming into cancer cells

New technique provides greater understanding of how drugs get in and out of cells in our bodies

Scientists identify molecular trick that may explain part of Salmonella's fierceness

UT Southwestern investigators test groundbreaking depression research in real-world setting

UT Southwestern surgeons complete the first Lap-Band weight-loss surgery in Texas using single incision as entry point

Industry supports international melanoma research

Rural, unmarried women at higher risk for depression

Australian Government oddly excludes AMA again on health plans - AMA negative about plans to ease GP shortage

AHF to Dr. Fauci and the CDC: "show us the AIDS numbers"

Age-adjusted death rates in U.S. down sharply in 2006

Smoking and obesity linked to hearing loss

Simple steps can help reduce your risk of contracting potentially deadly superbug

Researchers find gamma-secretase modulators being tested for Alzheimer’s work in unexpected and beneficial ways

Transforming Cardiovascular Care: Insights from Mina Makar at AstraZeneca

Clue's CEO Rhiannon White on the Future of Femtech and PCOS

Freezing Point Osmometry in Life Science Applications

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