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Drug topotecan shows promise against Wilms tumor

St. Jude researchers have shown that the drug topotecan holds promise as a treatment for the recurrent form of a kidney cancer called Wilms tumor, a solid tumor of the kidney that arises from immature kidney cells, and the fifth most common tumor among children.

17 Aug 2007

Painful memories toughest to leave behind

Painful, emotional memories that people would most like to forget may be the toughest to leave behind, especially when memories are created through visual cues, according to a new study by the University of North Carolina at Chapel Hill.

17 Aug 2007

Specific antagonism lowers blood pressure

High blood pressure (hypertension) is associated with an increased risk of heart attack and stroke, and the frequent use of drugs known as NSAIDs, for example to treat individuals with rheumatoid arthritis, can cause hypertension.

17 Aug 2007

Cannabis for allergic contact dermatitis

Administering a substance found in the cannabis plant can help the body's natural protective system alleviate an allergic skin disease (allergic contact dermatitis), an international group of researchers from Germany, Israel, Italy, Switzerland and the U.S. has found.

17 Aug 2007

Proteins involved in fragile X syndrome identified

The interplay of two proteins that bind to messenger RNA, a molecule that mediates translation of the information encoded in genes into proteins, triggers the appearance of fragile X-associated tremor/ataxia syndrome (FTAX), a late-life disorder associated with the gene that causes fragile X syndrome in children, said researchers from Baylor College of Medicine in Houston and Emory University School of Medicine in a report that appears today in the journal Neuron.

17 Aug 2007

New understanding of how HSV-1 attacks cells

A team of University of Kentucky researchers has identified the roles that herpes simplex virus type 1 (HSV-1) proteins play during the invasion of cells and the formation of skin lesions known as cold sores and fever blisters.

17 Aug 2007

Relapse from antidepressant medication may be lack of response to medication in the first place

A new study by Rhode Island Hospital researchers indicates that a relapse during antidepressant continuation treatment may be due to a relapse in patients who were not true drug responders.

17 Aug 2007

Reactivating a critical gene lost in kidney cancer reduces tumor growth

Researchers at Mayo Clinic Jacksonville, have found that a key gene is often silenced in clear cell renal cell carcinoma, the most common type of kidney cancer, and when they restored that gene in human kidney cancer cells in culture and animal experiments, tumors stopped growing and many disappeared.

17 Aug 2007

Prophylactic cranial irradiation in small cell lung cancer significantly increases survival

Prophylactic cranial irradiation after chemotherapy significantly reduces the risk of brain metastasis and doubles one-year survival in small-cell lung cancer (SCLC), according to the results of the multicenter phase III randomized EORTC trial 08993-22993, published in the New England Journal of Medicine.

17 Aug 2007

Pronouns light up brain!

New research suggests that pronouns may play a far greater role than simply replacing a proper name in a sentence. A University of South Carolina study suggests that pronouns help keep the brain's complex circuitry and limited memory system from being overloaded.

17 Aug 2007

Organ-transplant drug may help fight lupus

A compound related to a drug used in humans to prevent organ-transplant rejection attacks a key biochemical process in the faulty immune cells of lupus-prone mice, suggesting a possible new approach to combating the disease, UT Southwestern Medical Center researchers have found.

17 Aug 2007

PET MPI provides a more accurate "picture" of coronary obstruction

Physicians need to know how badly heart vessels are blocked before they can decide how to treat patients at risk of having a heart attack.

17 Aug 2007

Antibacterial soaps show no health benefits over plain soaps

Antibacterial soaps show no health benefits over plain soaps and, in fact, may render some common antibiotics less effective, says a University of Michigan public health professor.

17 Aug 2007

Scientists discover new mechanism for viral replication

Researchers at the University of Pennsylvania School of Medicine have identified a new strategy that Kaposi's Sarcoma Associated Herpesvirus (KSHV) uses to dupe infected cells into replicating its viral genome.

17 Aug 2007

Obesity and aversion to exercise could enhance the risk of pancreatic cancer

Obesity and aversion to exercise have become hallmarks of modern society and a new study suggests that a blood protein linked to these lifestyle factors may be an indicator for an increased risk of developing pancreatic cancer.

17 Aug 2007

Breakthrough pain medication

Cancer patients frequently experience two types of pain: persistent and breakthrough.

17 Aug 2007

Nicotinic receptors may be important targets for treatment of multiple addictions

For years, scientists have known that some people are biologically more susceptible to drug addiction than others, but they have only been able to speculate why.

17 Aug 2007

New target for the development of anti-influenza drugs

Scientists at Cure Lab, Inc., a biotechnology company based in Canton, Massachusetts, in collaboration with researchers at Boston University and Harvard Medical School have discovered a potential new target for the development of anti-influenza (flu) drugs, including those that may be effective against potentially pandemic influenza strains like H5N1.

17 Aug 2007

New prion protein 'Shadoo' discovered - may offer insight into mad cow disease

Scientists have discovered a new protein that may offer fresh insights into brain function in mad cow disease.

17 Aug 2007

Sirtuin protein instrumental in fat production and metabolism

A new Joslin Diabetes Center-led study has identified a protein found in fat cells that may play a major role in how fat is produced and stored, offering a new target for treatments to prevent obesity and reduce the risk for type 2 diabetes.

17 Aug 2007