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Antitumour drugs impede DNA uncoiling by topoisomerase I

The annoying bulges of an overwound telephone cord that shorten its reach and limit a caller's motion help explain why drugs called camptothecins are so effective in killing cancer cells, according to investigators led by Mary-Ann Bjornsti, Ph.D., at St. Jude Children’s Research Hospital, and Nynke Dekker, Ph.D., at Delft Technology University.

22 Aug 2007

Near-infrared resonant nanoshells for combined optical imaging and photothermal cancer therapy

Using metal nanoshells designed to both absorb and scatter near-infrared light, a team of investigators at Rice University has shown that such nanoparticles can both image and treat tumors in animals. Their experiments revealed complete tumor destruction in more than 80 percent of animals treated with these nanoshells.

22 Aug 2007

Nanotubes offer new approach to cancer radiotherapy

Radioactive elements, or radionuclides, are well-established anticancer agents whose main limitation is that they kill healthy cells almost as easily as they do tumors. But because nanoparticles can be targeted to tumors, researchers have seized on the idea of using nanoparticles to deliver radionuclides to tumors, thus sparing healthy tissues from radiation-induced damage.

22 Aug 2007

Multifunctional nanoparticles for combining ultrasonic tumor imaging and targeted chemotherapy

A new targeted drug delivery method, which combines two nanoparticles into one larger one, uses ultrasound to image tumors and release the anticancer drug doxorubicin from "nanobubbles" into the same tumors.

22 Aug 2007

Targeted quantum dot conjugates for siRNA delivery

Take a quantum dot, add a coating of poly(ethylene glycol) (PEG), and attach a homing peptide and a piece of small interfering RNA (siRNA), and the result is a targeted nanoparticle that can stop the production of a specific protein by a targeted cell.

22 Aug 2007

Vaccine suppresses aggregates of tau protein - implications for Alzheimer's

A new study by NYU Medical Center researchers shows for the first time that the immune system can combat the pathological form of tau protein, a key protein implicated in Alzheimer's disease.

22 Aug 2007

Geographical variation in the prevalence of problematic substance use in Canada

If you think the big cities of Toronto and Montreal have the highest rate of alcohol and drug use problems, think again.

22 Aug 2007

Drop-off in procedural experience of UK junior doctors

UK trainee doctors working in emergency care claim they are gaining less experience of common practical procedures, suggests a small study in Emergency Medicine Journal.

22 Aug 2007

Insulin pens may offer diabetics substantial savings

Diabetics who need to switch from oral medications to insulin could reduce their annual healthcare costs up to $17,000 by using an insulin pen instead of a syringe to deliver their daily dose of medication.

22 Aug 2007

Migration of antibiotic resistance from animal feeding operations into groundwater

The routine use of antibiotics in swine production can have unintended consequences, with antibiotic resistance genes sometimes leaking from waste lagoons into groundwater.

22 Aug 2007

Hemorrhoids tips

Are you tired of the itch and burn of hemorrhoids? While it's a fairly common condition, many patients may be too embarrassed to talk to their doctor about it.

22 Aug 2007

Benefits of vitamin D for cancer prevention

A new study looking at the relationship between vitamin D serum levels and the risk of colon and breast cancer across the globe has estimated the number of cases of cancer that could be prevented each year if vitamin D3 levels met the target proposed by researchers.

22 Aug 2007

Pomegranate juice does not impair clearance of oral or intravenous Midazolam

A study from the Tufts University School of Medicine published in the Journal of Clinical Pharmacology finds that pomegranate juice does not interact with oral or intravenous medication, contrary to previous information.

22 Aug 2007

Surgical options for severe intra-abdominal inflammation

Performing a repeat surgery for patients with peritonitis (severe intra-abdominal inflammation or infection) only when clinical improvement is lacking may have some advantages compared with having the repeat procedure routinely scheduled after the operation, according to a study in the August 22/29 issue of JAMA.

22 Aug 2007

Sewage reveals community-wide illegal drug use

Public health officials may soon be able to flush out more accurate estimates on illegal drug use in communities across the country thanks to screening test described at the 234 th national meeting of the American Chemical Society, the world's largest scientific society.

22 Aug 2007

High altitude pulmonary oedema

Experts at the University are studying an illness known as HAPE (high altitude pulmonary oedema), which causes fluid to build up in the lungs can and can occur from as low as 2,500 metres, affecting people of all age groups and fitness levels.

22 Aug 2007

Natural antimicrobial agents for food safety

Two items high on the list of public concerns are the need for greater food safety and a growing demand for natural or organic food products.

22 Aug 2007

Non-medicinal interventions for young children with ADHD

Non-medicinal interventions are highly effective in preventing the behavioral and academic problems associated with Attention Deficit Hyperactivity Disorder (ADHD), according to a five-year study led by researchers at Lehigh University's College of Education.

22 Aug 2007

Study looks at in-hospital weight loss of newborns

Healthy, full-term newborn babies tend to lose weight during the first few days after their birth. A groundbreaking new study published in the latest issue of the Journal of Human Lactation explores the reasons why certain newborns lose more (or less) than others and what conclusions can be drawn from the research.

22 Aug 2007

Who's still smoking?

Quitting smoking is not easy, but thousands of New Yorkers succeed at it every year. Who's trying to kick the habit, and who's succeeding? In a new report titled Who's Still Smoking?, the Health Department sheds light on both questions.

22 Aug 2007