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High levels of immunosuppressant may lead to tumor recurrence

A new study on the incidence of liver cancer after transplant found that high levels of the immunosuppressant cyclosporine favored tumor recurrence and identified blood levels of the drug that should not be exceeded. Lower levels of cyclosporine levels did not affect rejection rates.

22 Apr 2005

Aging population correlates with a switch from acute infectious diseases to chronic diseases as the major cause of morbidity and mortality

Some diseases like ulcers and certain types of cancer, once thought to be primarily related to lifestyle factors, are now known to be caused by microorganisms, and many more syndromes, including some psychiatric conditions, may have a connection to infection, according to a report released today by the American Academy of Microbiology.

22 Apr 2005

Rare surgery performed to remove pancreas, prevent diabetes and ease pain of chronic pancreatitis

In a 12-hour, dual-stage surgery known to be performed at only two other centers in the U.S., doctors at the University of Alabama at Birmingham (UAB) on Tuesday returned a patient's own insulin-producing cells to him after surgically removing his pancreas to eliminate constant, severe pain from chronic pancreatitis.

22 Apr 2005

Mice put into "suspended animation" in U.S.

Researchers from the University of Washington and the Fred Hutchinson Cancer Research Centre in Seattle have placed mice in a state of near suspended animation, raising the possibility that in future hibernation could be induced in humans.

22 Apr 2005

First confirmed case of Mad Cow disease in Holland

The first known case of the human form of "mad cow disease" - known as variant Creutzfeldt-Jakob Disease (vCJD), has been diagnosed in the Netherlands.

22 Apr 2005

Almost all killer flu bug kits destroyed

99 percent of the kits containing a killer flu bug that mistakenly ended up in thousands of laboratories around the world, sparking fears of a pandemic, have been destroyed, according to top U.S. health official Dr. Julie Gerberding, director of the Centers for Disease Control and Prevention (CDC).

22 Apr 2005

Suicide link with epilepsy drugs examined

The U.S. Food and Drug Administration (FDA), is asking 14 drug manufacturers to check their data for any evidence that epilepsy drugs trigger suicidal thoughts or behaviour.

22 Apr 2005

Researchers make gains in understanding antibiotic resistance

Howard Hughes Medical Institute researchers chiseling away at the problem of antibiotic resistance now have a detailed explanation of how the drugs' main cellular target in bacteria evolves to become resistant to some of these medications.

22 Apr 2005

Genetic variation linked to alcohol dependence

The same gene that accounts for part of a genetic risk for developing alcoholism in a U.S. population is found in a Russian population, according to a published study by a Yale School of Medicine researcher.

22 Apr 2005

Brain system that controls the sleep/wake cycle might also play a role in regulating appetite and metabolism

A new mouse study suggests that a brain system that controls the sleep/wake cycle might also play a role in regulating appetite and metabolism. Mice with a mutation in a gene called "Clock," which helps drive circadian rhythm, ate significantly more and gained more weight.

22 Apr 2005

Scientists weaponize an antibody to deliver continuous attacks on cancer cells

In a recent study published in Molecular Cancer Therapeutics, researchers at the Weizmann Institute of Science paired the active ingredient of a garden remedy with advanced bio-technology to deliver a powerful punch against cancer. The cancer killing effectiveness lies in their technique of arming a cancer-targeting antibody with the destructive potential of the dietary molecule otherwise known as "allicin."

22 Apr 2005

Cancer patients may one day benefit from treatment with mixtures of customized antibodies

In a study published recently in the Proceedings of the National Academy of Sciences (USA), a team of Weizmann Institute scientists have demonstrated how the right combination might form a web that destroys the cancer cell's communication network, ultimately demobilizing the cell.

22 Apr 2005

Propensity for obesity, diabetes may occur in utero

The adage "You are what you eat" should be rephrased to include "and so are your children," based on metabolic research pioneered by researchers at the University at Buffalo.

22 Apr 2005

One step closer to personalized medical treatment

A new study by 64 renowned scientists may bring us one step closer to personalized medical treatment--that is, medical treatment tailored to each person's unique genetic make-up and medical condition.

22 Apr 2005

New strategy to identify differences between non-metastatic and highly metastatic breast cancer cells

Researchers at the University of California, San Diego have used a new strategy to identify differences between non-metastatic and highly metastatic breast cancer cells. The article by Valerie Montel et al., "Expression profiling of primary tumors and matched lymphatic and lung metastases in a xenogeneic breast cancer model," appears in the May 2005 issue of The American Journal of Pathology and is accompanied by a commentary.

22 Apr 2005

Enzyme that helps trigger the development of leukemia

Scientists at the University of North Carolina at Chapel Hill have identified an enzyme that helps trigger the development of leukemia, a cancer of blood cells.

21 Apr 2005

Discovery may lead to new drugs to prevent sexually transmitted HIV infection

Scientists have long suspected that HIV hijacks immune cells called dendritic cells to infiltrate the immune system. Now UCLA AIDS Institute researchers have shown that blocking HIV's access to a naturally occurring molecule on dendritic cells may cut their ability to smuggle the virus into other immune cells.

21 Apr 2005

Neural tube defects decrease with folic acid fortification

A new study published online April 21, 2005 in the American Journal of Medical Genetics Part A examines whether the recent decline in neural tube defects in Chile was due to the addition of folic acid to wheat flour in that country or to pre-existing decreasing trends. The journal is available online via Wiley InterScience.

21 Apr 2005

First time video capture of chemical signals that traverse human cells messaging

Researchers at UCSD and UC Irvine have captured on video for the first time chemical signals that traverse human cells in response to tiny mechanical jabs, like waves spreading from pebbles tossed into a pond. The scientists released the videos and technical details that explain how the visualization effect was created as part of a paper published in the April 21 issue of Nature.

21 Apr 2005

With a complement, the sperm gets the egg

When a sperm fuses with an egg, a specific reaction takes place that exposes the inner membrane of the spermatozoa, where a protein called the complement regulator membrane cofactor protein (MCP) is expressed. MCP is an immune regulatory molecule and its presence in reproductive tissues was unclear.

21 Apr 2005