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Benefits of lung cancer screening with CT questioned

Annual screening with helical computed tomography (CT) can help radiologists detect lung cancers at their earliest, most curable stage, but has not been shown to reduce mortality from the disease, according to a study published in the April issue of the journal Radiology.

28 Mar 2005

Research tool for turning off genes may eventually have therapeutic application

A research team based at Massachusetts General Hospital (MGH) has identified 80 new genes essential to the process of RNA interference (RNAi), a powerful new research tool for inactivating genes in plants or animals.

28 Mar 2005

Marburg death toll in Angola now up to 122

Carlos Alberto, a spokesman for the Angolan health ministry, says the death toll in the Marburg hemorrhagic fever outbreak in Angola has now risen to 122, just one fewer than in the largest previous outbreak of the disease, in the Democratic Republic of the Congo from 1998 to 200 and killed 123 of 149 people infected.

28 Mar 2005

Use of DNA-damaging agents revolutionizes chemotherapy against a wide variety of cancers

A new study demonstrates the potential effectiveness of treating tumors by combining agents that damage DNA with a drug that sensitizes cancer cells to these agents.

28 Mar 2005

Three different leukemias are all caused by mutations that alter a specific enzyme controlling blood cell proliferation

Identifying the genetic malfunction that causes these disorders raises the hope that researchers may be able to devise a targeted therapy, just as they have done for chronic myelogenous leukemia (CML), which is presently treated with Gleevec. The three leukemias that share a common genetic cause are polycythemia vera (PV), essential thrombocythemia (ET) and myeloid metaplasia with myelofibrosis (MMM).

28 Mar 2005

Test that will prevent the needless loss of the thyroid gland in people with the noncancerous condition

New research suggests that physicians can distinguish between a type of thyroid cancer and an identical-looking, non-cancerous thyroid condition by simply determining the activity of three genes.

28 Mar 2005

E. coli petting zoo link in Florida

A 12-year-old girl's death is being investigated for possible links to an outbreak of E. coli bacterial infections among people who attended one of two fairs in early March that included petting zoos, the Strawberry Festival in Plant City and the Central Florida Fair in Orlando.

28 Mar 2005

Genome in gut bacterium key to intestinal health

A bacterium that lives in the human gut adaptively shifts more than a quarter of its genes into high gear when its host's diet changes from sugar to complex carbohydrates.

28 Mar 2005

New therapy for treating cat allergies looks promising

Andrew Saxon, M.D., and a team of researchers at University of California, Los Angeles (UCLA) have found that a molecule designed to block cat allergies can prevent allergic reactions in laboratory mice and was also successful when tested on human cells in a test tube.

28 Mar 2005

Hope of new treatments for liver damage

There is currently no cure for liver cirrhosis and a patient's only hope of survival is to receive a liver transplant.

28 Mar 2005

Primary care office strategies may increase colon cancer screening

Patients are more likely to receive colorectal cancer screening when primary care practices use an office systems approach, according to an article in the March 28 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

28 Mar 2005

Fish is brain food

Researchers with the Department of Veterans Affairs (VA) and the University of California at Los Angeles (UCLA) found that a diet high in docosahexenoic acid, or DHA--an omega-3 fatty acid found in relatively high concentrations in cold-water fish--dramatically slowed the progression of Alzheimer's disease in mice.

28 Mar 2005

Child care may affect entire community's risks of infection

Any parent knows how quickly a cold or a cough can spread between children who play together. However, child care may also affect an entire community's carriage of potentially dangerous bacteria known as Streptococcus pneumoniae, according to an article in the April 1 issue of Clinical Infectious Diseases, now available online.

28 Mar 2005

New insights into Pemphigus

Pemphigus is a deadly skin blistering disease that occurs when patients' produce antibodies that attack proteins in their own cells – called autoantibodies.

28 Mar 2005

Risky surgery not always necessary to treat cervical disease

Revolutionary advancements in the treatment options for diseases associated with human papillomavirus (HPV) now include nonsurgical options such as chemoprevention and vaccines. A review of these methods is published in the latest issue of the International Journal of Gynecological Cancer.

28 Mar 2005

Why it's important for older people to exercise

Researchers now have the physical evidence to show why it's important for older people to exercise. And it comes with the discovery that, in aging racehorses, regular aerobic workouts decreased the prevalence of muscle damage that can be caused by exertion.

28 Mar 2005

Latest findings in male reproduction research

The XVIII North American Testis Workshop, chaired by Population Council senior scientist Matthew Hardy, will be held 30 March - 2 April in Seattle, Washington. Participants will discuss findings from the large body of recent research on male reproduction.

28 Mar 2005

Retirement communities need to do more to help residents cope with loneliness and depression

As the nation’s population ages, greater numbers of people are moving into assisted living and other retirement communities. While these facilities offer many advantages to the elderly, a recent research article concludes that they should consider doing more to alleviate the loneliness and depression that their residents often experience.

28 Mar 2005

Children sick after zoo visit - Florida Officials investigate

Health officials in Florida report that five children are in a critical condition with kidney failure and may have picked up a rare infection at petting zoos.

28 Mar 2005

New estimates of the causes of child mortality worldwide

Seventy-three percent of the 10.6 million child deaths worldwide each year are the result of six causes: pneumonia, diarrhea, malaria, neonatal sepsis, preterm delivery and asphyxia at birth.

28 Mar 2005