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Promising new evidence for the optimal use of biologic therapies for rheumatoid arthritis

A major cause of pain and disability, rheumatoid arthritis (RA) is also potentially the most treatable form of chronic arthritis. Researchers, doctors, and patients agree that a group of drugs called disease-modifying antirheumatic drugs (DMARDs) can effectively reduce joint pain and stiffness.

7 Jan 2005

Strong association between high levels of hyaluronic acid and severe osteoarthritis

A chronic degenerative joint disease, osteoarthritis (OA) is a common cause of pain and disability among older Americans. OA of the knee affects up to 6 percent of the older population, while OA of the hip affects about another 3 percent. While treatments vary, there is hope that early intervention – before joint destruction can be clearly seen and measured on an X-ray image-will improve outcomes.

7 Jan 2005

Fallout from Vioxx and Celebrex market recall challenges industry

The pharmaceutical and biotechnology industries face further marketing and sales challenges in 2005 as the fallout from the Vioxx and Celebrex market recall and warning make it increasingly challenging for companies across the industry to reach physicians and consumers with effective campaigns without the distractions of the unfavorable press these recent events have generated.

7 Jan 2005

FDA clearance to test influenza vaccine, Fluviral

ID Biomedical Corporation announced today that it has received clearance from the U.S. Food and Drug Administration (FDA) to begin immediate clinical testing of its influenza vaccine, Fluviral, in the United States under an Investigational New Drug application (IND).

7 Jan 2005

Potential cure for lymphoma in HIV patients

Stem cell transplants have become the standard of care for patients with relapsed lymphoma, but not for patients who suffer from both this disease and HIV.

7 Jan 2005

Hormone replacement therapy associated with increased risk of stroke

Hormone replacement therapy (HRT) is associated with an increased risk of stroke, especially ischaemic stroke, finds a review of trials published on bmj.com today.

7 Jan 2005

Injuries and deaths caused by unexploded ordnance in Afghanistan

Unexploded military material in Afghanistan cause more injuries and deaths than landmines especially among children, according to research published on bmj.com today.

7 Jan 2005

Financial barriers to a career in medicine are growing

The financial barriers to a career in medicine are growing, the BMA says today (Friday 7 January 2005), as new figures show the average fifth year medical student is in debt by £19,248 - 16% higher than last year - and many owe more than £30,000.

7 Jan 2005

Most alcohol-related plane crashes occur at night and in poor weather

Researchers at Johns Hopkins have found that nighttime flying and worsening weather conditions are two key characteristics of fatal plane crashes in general aviation where alcohol consumption by the pilot was also a factor.

7 Jan 2005

Treatment centres threaten NHS Trusts

Responding to the Secretary of State for Health, John Reid's, report today (7 January 2005) on NHS and Independent Treatment Centres, the Chairman of the BMA's Consultants' Committee, Dr Paul Miller, warned that the centres were destabilising NHS hospitals.

7 Jan 2005

First program to apply RNA interference (RNAi) technology to asthma

Sirna Therapeutics, Inc. has announced the first program to apply RNA interference (RNAi) technology to asthma, a highly prevalent, chronic disease accounting for an estimated $13 billion in healthcare costs in the United States, a number which is forecast to grow considerably by the end of the decade.

7 Jan 2005

New guidelines for treating diabetes

Every year, the American Diabetes Association (ADA) issues Clinical Practice Recommendations, a series of updated recommendations to help health care providers treat people with diabetes using the most current research available.

7 Jan 2005

New form of treatment for cancer of the larynx

Surgeons at Montefiore Medical Center are using a new form of treatment for cancer of the larynx that allows for quicker recovery and shorter hospital stays, and saves the voice box so patients retain the ability to speak.

7 Jan 2005

Peginterferon alfa-2b produced sustained responses in patients with chronic hepatitis B

Results from a large international clinical study reported in this week's issue of The Lancet showed that peginterferon alfa-2b produced sustained responses in patients with chronic hepatitis B. The investigator-initiated study is the largest clinical trial to date with peginterferon alfa-2b therapy for chronic hepatitis B.

7 Jan 2005

Ascorbic acid doesn't seem to help physical exercise performance

Orange juice or other sources of vitamin C (ascorbic acid), may (or may not) benefit you in terms of health and exercise, but contrary to what many people thought previously, ascorbic acid doesn't seem to help physical exercise performance.

6 Jan 2005

Now significantly easier to search long stretches of DNA for genetic changes associated with disease

The researchers developed a method called direct genomic selection that accelerates the transition between family or population-based studies of disease inheritance patterns and identification of genetic variations that may contribute to disease.

6 Jan 2005

Protein discovery with medical implications

It was a transforming moment. Researchers could barely believe their eyes. A molecular blob of a protein reshaped itself into a molecular Pacman in order to free new viruses from the inside of a bacterial cell.

6 Jan 2005

Researchers want to see physicians reevaluate the drugs their elderly patients take to determine if they are appropriate

Just as our bodies physically slow down as we age, changes occur in the way that older bodies handle pharmaceuticals, and prescribing physicians need to be aware of those medications inappropriate for the elderly.

6 Jan 2005

Discovery could lead to a screening test that identifies people who have a higher or lower susceptibility to HIV/AIDS

People with more copies of a gene that helps to fight HIV are less likely to become infected with the virus or to develop AIDS than those of the same geographical ancestry, such as European Americans, who have fewer copies of the gene, according to a study funded by the National Institute of Allergy and Infectious Diseases (NIAID).

6 Jan 2005

Single abnormal cell can duplicate to form cancerous tumors

Researchers at the University of Pittsburgh have identified how a single aberrant cell can duplicate to form cancerous tumors, suggesting a specific protein mechanism as a target for the treatment of cancer, they report in a paper titled "Spindle Multipolarity Is Prevented by Centrosomal Clustering," published in the Jan. 7 issue of Science.

6 Jan 2005