Structure of bacteriophage shown to resemble a human virus

Jun 26 2006

New research has revealed that the structure of a bacteriophage, a virus infecting bacteria, resembles that of certain dangerous viruses that infect people.

Studying this bacteriophage reveals various characteristics about viruses and their life cycle without having to study actual human viruses.

Structural biologists Juha Huiskonen and Sarah Butcher from the Academy of Finland Virus Research Centre of Excellence, University of Helsinki, have determined the structure of the double-stranded RNA virus (phi6) in co-operation with their colleagues in the European Molecular Biology Laboratory (EMBL). The virus in question is a bacteriophage, which means that instead of eukaryotic cells it infects bacteria. To the researchers' surprise, its structure turned out to be very similar to human viruses, such as rotavirus. Rotaviruses are the most common cause of severe diarrhoea, particularly in neonatal babies and young children. Diarrhoea is one of the main causes of infant mortality in developing countries.

By studying the viruses in bacteria, researchers can determine various characteristics about the life cycle of viruses that are much harder to study using dangerous human viruses. The newly described structure of the bacteriophage furthers researchers’ understanding of how the particles of the double-stranded RNA virus are formed in the host cell. However, it is still unclear how the virus distinguishes its’ own genetic information from that of other corresponding cellular molecules. Studying these events with the bacteriophage will help the understanding of similar events in human viruses.

The similarity of double-stranded RNA viruses that infect different organisms is probably due to their mutual, primitive origin. During evolution, the basic structure has been maintained even though the gene sequences of the viruses have changed dramatically. Corresponding similarities between different viruses have earlier been detected between a double-stranded DNA bacteriophage and an archaeal virus.

The structure of the bacteriophage was studied with electron microscopy and computational methods.