Vitamin supplements no benefit to women's heart health

Aug 14 2007

Researchers in the U.S. say middle-aged women at risk for heart disease derive little benefit from taking vitamins C, E or beta carotene.

The researchers say eating a diet rich in those vitamins does benefit the heart.

A new study by researchers at Brigham and Women's Hospital and Harvard Medical School in Boston says vitamin supplements may not reflect the complex vitamins and nutrients found in foods, which possibly explains the discrepancies between most intervention trials and studies of fruits and vegetables.

Experts say a nutritious diet rich in the vitamins which protect the body's cardiovascular system counteract compounds known as "free radicals" which are harmful as they build up in the body and can damage artery linings, encourage blood clots and alter the function of blood vessels.

Study author Nancy Cook says though additional research into combinations of agents, particularly for stroke, may be of interest, widespread use of these individual agents for cardiovascular protection does not appear to be warranted.

Cook's study involved 8,171 women with an average age of 60.6, who were monitored for roughly nine years for fatal heart disease, heart attacks, strokes and heart-related surgery.

The women, who either had a history of cardiovascular disease or three or more risk factors, were randomly assigned to take 500 milligrams of ascorbic acid (vitamin C) or placebo every day; 600 international units of vitamin E or placebo every other day; and 50 milligrams of beta carotene or placebo every other day.

During the study period of on average 9.4 years, 1,450 women had one or more cardiovascular events, including 274 heart attacks, 298 strokes, 889 coronary revascularization procedures (bypass surgery or angioplasty) and 395 cardiovascular deaths (out of a total 995 deaths).

The research revealed that only a combination of vitamins C and E conferred a slightly lower risk of stroke compared to placebos.

But the study also found that taking the supplements did not harm the women, as some recent research has suggested.

Heart disease is the leading cause of death in the industrialized world and experts say supplements cannot be expected to reverse 30 years of heart disease.

Some studies have shown that supplements with modest amounts of antioxidants do confer some benefits over a long period of time.

The study is published in the Archives of Internal Medicine.