Most UK citizens susceptible to hep B infection

Nov 13 2007

The failure of the UK to introduce universal hepatitis B immunisation means that most UK citizens are susceptible to infection, warns an infectious diseases expert in this week's BMJ.

The UK is one of the few developed countries that still does not routinely immunise children against hepatitis B, despite a call by the World Health Organisation for the global introduction of vaccine prevention programmes by 1997, writes Andrew Pollard, Reader in Paediatric Infection and Immunity at Oxford University.

Earlier this year, the BMA also called upon the Department of Health “to introduce the hepatitis B vaccine into the childhood schedule without further delay.”

The main argument against introducing universal immunisation is the relatively low incidence of disease in the UK compared with other countries. However, 180,000 people in the UK are chronically infected with hepatitis B virus and 7,700 new cases of chronic infection are detected each year.

Growing travel and migration also put the UK population at risk of exposure from abroad.

Up to 40% of infections are transmitted from mother to child during birth, or in early childhood through contact with blood or body fluids. Fortunately, the virus can be controlled and, possibly, eventually eliminated by immunisation, says Pollard.

Indeed, countries that have introduced universal childhood immunisation in the past 15 years now have a new generation of adolescents and young adults among whom transmission is being interrupted.

The UK government currently favours a targeted immunisation strategy to prevent transmission of the virus from mother to child. But the easiest and cheapest way to protect UK children is to add hepatitis B vaccine to the current UK primary immunisation schedule in early infancy, says Pollard. This approach is already widely used in Europe.

However, at this time, infant immunisation alone is also insufficient to limit transmission of the virus, because of ongoing transmission among the non-immune adult population and the difficulty in identifying and reaching people at risk. For this reason, Pollard argues that the current targeted programme aimed at high risk groups (injecting drug users, prisoners etc) needs strengthening to reduce the burden of new infections until those in a universal immunisation programme reach adulthood.

He also says that the recent proposal to introduce vaccination to prevent cervical cancer in pre-adolescents from next year could provide a vehicle for implementing a concomitant adolescent hepatitis B programme to prevent liver cancer. This, he suggests, would generate a group of immune individiuals more quickly than universal infant immunisation alone and hasten the control of the hepatitis B virus in the UK.