Cannabis chemicals halt prostate cancer growth

Aug 26 2009

Active chemicals in cannabis have been shown to halt prostate cancer cell growth according to research published in the British Journal of Cancer.

Researchers from the University of Alcala, in Madrid tested the effects of the active chemicals in cannabis called cannabinoids on three human prostate cancer cell lines - called PC-3, DU-a45 and LNCaP.

The prostate cancer cells carry molecular "garages"" called receptors - in which cannabinoids can 'park'.

The scientists showed for the first time that if cannabinoids "park" on a receptor called CB2, the cancer cells stop multipyling.

But Dr Lesley Walker, Cancer Research UK's director of cancer information warned patients against smoking the drug. She said: "This is interesting research which opens a new avenue to explore potential drug targets but it is at a very early stage - it absolutely isn't the case that men might be able to fight prostate cancer by smoking cannabis."

Dr Walker added: "This research suggest that prostate cancer cells might stop growing if they are treated with chemicals found in cannabis but more work needs to be done to explore the potential of the cannabinoids in treatment."

To confirm the findings the scientists switched off the CB2 receptors - or 'closed the garage doors'- on the prostate cells. When cannabinoids were then added to cells without the CB2 receptor, the prostate cancer cells carried on dividing and growing. This suggests that cannabinoids connect with the CB2 receptors on prostate cancer cells to stop cell division and spread.

Professor Ines Diaz-Laviada, study author at the University of Alcala said: "Our research shows that there are areas on prostate cancer cells which can recognise and talk to chemicals found in cannabis called cannabinoids. These chemicals can stop the division and growth of prostate cancer cells and could become a target for new research into potential drugs to treat prostate cancer."

Prostate cancer is the most common cancer in men in the UK- affecting more than 35,000 men in the UK each year. A quarter of all new cases of cancer diagnosed in men are prostate cancers.

Notes: *Inhibition of human tumour prostate PC-3 cell growth by cannabinoids R (+)-Methanandamide and JWH-015: Involvement of CB2. British Journal of Cancer.

**The cannabinoids used were called R(+)-Methanandamide (MET) and JWH-015. The research was both in mice and also on the cells separately.