Second-quarter 2009 operating highlights announced by Helicos Biosciences

Helicos BioSciences Corporation (NASDAQ: HLCS) announced today its operating highlights for the quarter ended June 30, 2009 and other recent developments following the filing of its Quarterly Report on Form 10-Q for the period ended June 30, 2009.

“In the second quarter of 2009, we continued to deploy our Helicos™ Genetic Analysis System and to advance our technology. The number of installation sites doubled during the second quarter following the installation of our systems in some of the world’s most distinguished research sites. We also proudly congratulate the Stanford team for using their HeliScope™ Sequencer to publish the first ever single-molecule view of a whole human genome. I am pleased to see Helicos gaining commercial momentum in the marketplace and our technology producing scientific results that distinguish single molecule sequencing,” said Ronald A. Lowy, Helicos Chief Executive Officer.

Helicos’s unique True Single Molecule Sequencing (tSMS)™ technology allows scientists and clinical researchers to accurately sequence and quantitate DNA, including minute amounts of ancient and degraded DNA, without amplification or ligation, eliminating the biases inherent in those techniques, and providing increases in throughput and reductions in cost that enable breakthrough scientific research.

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