Study reveals interaction of genetic and environmental factors in the pathogenesis of Parkinson's disease

Gene variant influences vitamin B6 metabolism

"Our study reveals the interaction of genetic and environmental factors such as dietary habits in the pathogenesis of Parkinson's disease," explained Dr. Matthias Elstner of the Neurological Clinic of LMU and Helmholtz Zentrum M-nchen, lead author of the study. In addition, this genome-wide expression and association study confirms that vitamin B6 status and metabolism significantly influence both disease risk and therapy response (Annals of Neurology, January, 2010).

Scientists of the two Munich universities and Helmholtz Zentrum M-nchen investigated neurons in the brain to determine which genes modify their activity in Parkinson's disease. Among other findings, the research group detected increased activity of the pyridoxal kinase gene. In a subsequent international cooperation project, the researchers compared this gene in over 1,200 Parkinson patients with the genetic data of more than 2,800 healthy test subjects. In doing so, they discovered a gene variant which increases the risk for Parkinson's disease and which may lead to a modified quantity or activity of the enzyme pyridoxal kinase (PDXK) in the brain. In combination with genetic association analysis, the innovative method used here - single cell expression profiling of dopaminergic neurons - opens up new possibilities for analyzing genetic risk factors.

PDXK converts Vitamin B6 from food sources into its physiologically active form, which is the prerequisite for the production of the neurotransmitter dopamine. Parkinson's disease is linked to the accelerated aging and dying off of neurons that produce dopamine. The decreased synthesis of this neurotransmitter explains most of the disease symptoms: The gradual progression of the neurological disease is accompanied by muscle rigor and tremor and a slowing of movement (bradykinesia). Besides the constraints on daily life caused by these symptoms, the postural instability of the body can lead to dangerous falls. Moreover, in the course of the disease sensory symptoms like paresthesia, vegetative disorders (e.g. bladder dysfunction) and depression as well as other psychological changes can occur.

"Our study elucidates how genetic and environmental factors such as dietary habits interact in the pathogenesis of Parkinson's disease," explained Dr. Matthias Elstner of the Neurological Clinic of LMU and Helmholtz Zentrum M-nchen, who is lead author of the study. Dr. Holger Prokisch, head of the research team studying mitochondrial diseases at Helmholtz Zentrum M-nchen and TU M-nchen, added: "Although this variant is responsible for only a slight contribution to the overall risk for Parkinson's disease, our findings could aid in developing individualized therapies. "

Source: Helmholtz Zentrum M�nchen - German Research Center for Environmental Health