Can-Fite BioPharma files patent application for treatment of Uveitis with A3 adenosine receptor ligands

Can-Fite BioPharma Ltd, a biopharmaceutical company, traded on the TASE (TASE:CFBI) and developing anti- inflammatory and anti-cancer drugs, announced today the filing of a patent application, in conjunction with the United Stated National Institutes of Health (NIH), for the treatment of Uveitis with its A3 adenosine receptor ligands. Uveitis is the third ophthalmology indication being pursued by Can-Fite, in addition to Dry Eye Syndrome and Glaucoma. Can-Fite successfully concluded a Phase II clinical study in patients with dry eye syndrome recently, and is currently conducting a Phase II clinical trial in patients with Glaucoma or Ocular Hypertension.

“the current standard of care for patients with uveitis is steroids and systemic immunosuppressive therapy. The lack of specific drugs for the treatment of this condition creates a need for novel targeted therapies such as the products Can-Fite develops.”

Can-Fite and the National Eye Institute of the NIH, which collaborate under a Material-Transfer Cooperative Research and Development Agreement (M-CRADA), conducted animal studies which demonstrated the efficacy of Can-Fite’s lead molecule, CF101, in the treatment of experimental autoimmune uveitis. The submitted patent application protects the use of A3 adenosine receptor agonists for the treatment of Uveitis. Can-Fite is a leading company in the development of A3 adenosine receptors agonists for the treatment of human disease.

Uveitis is a chronic inflammatory disease that involves the internal parts of the eye. This disease can lead to severe pain and partial or complete vision loss. In some cases, uveitis is associated with other autoimmune diseases such as rheumatoid arthritis and Behcet's disease.

Prof. Pnina Fishman, CEO of Can-Fite, said today that "the current standard of care for patients with uveitis is steroids and systemic immunosuppressive therapy. The lack of specific drugs for the treatment of this condition creates a need for novel targeted therapies such as the products Can-Fite develops."

Source Can-Fite BioPharma Ltd

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