New study investigates effects of influenza among pregnant women

Norwegian Institute of Public HealthMar 25 2010

This spring, pregnant women in Bergen and Oslo will be invited to take part in the Norwegian Influenza Study (NorFlu). The aim is to find out how influenza in pregnancy affects maternal health and childhood development. NorFlu will also study any implications of vaccination during pregnancy.

In October, November and December 2009, a wave of swine influenza spread in Norway. Many young people and pregnant women became ill, but fortunately the epidemic was less serious than anticipated. Nevertheless, it is important to find out if the virus had any effect on pregnancies or foetuses. Therefore, NorFlu is recruiting approximately 4000 pregnant women in Bergen and Oslo. These women are now in their last trimester of pregnancy and were therefore potentially exposed to the virus late last year.

Most pregnant women who contract influenza complete their pregnancy without any problems. Pregnant women who have swine influenza are at greater risk than others of developing complications such as pneumonia and respiratory failure. Serious complications could lead to miscarriage or premature birth. Therefore, the Norwegian health authorities recommended vaccination in the second and third trimester of pregnancy. This was the same advice given by WHO and health authorities in the majority of countries that offered the pandemic vaccine.

Participants in NorFlu will be asked to complete a questionnaire and give a blood sample. It is important that both women who have had influenza as well as those who have not been sick participate. Research will concentrate on influenza among pregnant women and the effects of vaccination and medicine use, but will also highlight how genetic disposition, exposure to infectious disease and other environmental factors can affect physical and mental health.

Only anonymised material will be made available to researchers. It will be impossible to identify participants in NorFlu when the results are published.