Interim results from Micromet's MT110 BiTE antibody Phase 1 trial presented at ASCO

Jun 8 2010

Micromet, Inc. (Nasdaq: MITI), a biopharmaceutical company focused on the development and commercialization of next-generation antibodies for the treatment of cancer, today announced the presentation of updated interim results from a Phase 1 trial of the Company's BiTE antibody MT110 in patients with advanced solid tumors.   MT110 is designed to direct a patient's T cells, the immune system's most potent killer cells, against cancer cells that express the epithelial cell adhesion molecule (EpCAM).  Professor Walter Fiedler, University Hospital Hamburg-Eppendorf, Germany and the study's principal investigator, presented the data today at the American Society of Clinical Oncology Annual Meeting in Chicago, IL.

As of May 2010, 28 patients with locally advanced, recurrent or metastatic colorectal, gastric, and lung cancer have been treated with MT110 at dose levels ranging from 1 to 24 micrograms per day, in four week treatment cycles. 62% of the enrolled patients had received more than three prior lines of chemotherapy.

Out of 22 patients evaluable for response, disease stabilization was observed in nine patients, with a median duration of 91 days.  Consistent with the BiTE mode of action, investigators observed redistribution and expansion of T cells in blood, and infiltration of T cells into tumor tissue. The majority of adverse events were Grade 1 and 2, including fever and nausea. Transient increases in liver laboratory parameters have been observed in the majority of patients at the start of treatment. A new dosing schedule was implemented to reduce the liver enzyme levels at the onset of treatment. To date, no maximum tolerated dose has been reached and dose escalation continues.

"We look forward to continuing dose escalation in the on-going study and exploring the activity of MT110 in an expanded patient population that includes additional solid tumor indications with a high level of EpCAM expression, such as breast, prostate and ovarian cancer," said Christian Itin, Ph.D., Micromet's President and Chief Executive Officer.