The Alzheimer's Drug Discovery Foundation (ADDF) announced today that it has awarded a grant of $228,668 to Cognition Therapeutics (CogRx) to develop small molecule drugs that block the action of the toxic "oligomers" thought responsible for Alzheimer's disease (AD).
CogRx's small-molecule drug candidates have the potential to become first-in-class drug candidates specifically targeting soluble oligomers. The company used its biology platform to screen a proprietary central nervous system-biased chemical library and identified a number of novel, highly brain penetrate small molecule drug candidates that reverse the learning and memory deficits in an animal model of AD. The ADDF's grant will fund further characterization in rodent AD models as well as other preclinical work required to advance the company's drug candidates to human trials.
"CogRx is one of the first companies to demonstrate this kind of robust registration between its in vitro biology platform and complex behavioral models of memory and learning," said CogRx's Chief Scientific Officer, Susan Catalano, PhD. "Our assays reflect functional biological responses of neurons to the toxic soluble oligomers and thus capture effects on multiple molecular targets."
"CogRx has developed several promising small molecules that inhibit the pathological effects of beta-amyloid oligomers in cell cultures and improve behavior in animal models," said the ADDF's Executive Director Howard Fillit, MD. "The ADDF funding will accelerate the CogRx drug candidates towards the clinic."
Hank Safferstein, PhD, JD, CogRx's CEO, said: "This funding will support the work necessary to achieve IND filing of a drug candidate. We look forward to working closely with the ADDF and our own Scientific Advisory Board to discover and develop therapies which have been designed to halt or reverse the devastating effects of AD in elderly patients."
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