Myotec, Hybrid merge to form PsiOxus Therapeutics

Myotec Therapeutics, Ltd. (Myotec) and Hybrid BioSystems, Ltd. (Hybrid) today announced their merger to form PsiOxus Therapeutics, Ltd. (PsiOxus), a new, development stage biotechnology company using non-traditional approaches to novel therapeutics for cancer and wasting diseases. PsiOxus, which will be led by CEO Dr. John Beadle, boasts a combined pipeline of phase I and II clinical stage assets. This pipeline will be supported with an additional financing round of £3.6 million ($5.8 million), led by Imperial Innovations and with participation from all of the major investors from both of the merged predecessor companies.

PsiOxus' lead candidate is MT-102, a dual action Anabolic Catabolic Transforming Agent (ACTA) in phase II clinical development for the treatment of cachexia, a wasting disease that is the direct cause of death in 20 to 40 percent of all cancer patients. MT-102 is also in development for sarcopenia, the age related loss of muscle mass and strength that affects one in five people by age 60. The human safety profile of MT-102 has been demonstrated in two phase I/II clinical studies, and the efficacy profile has been demonstrated in preclinical studies. The Company has initiated a multinational, double blind, placebo controlled phase II clinical study, which will be reported in 2011.

PsiOxus is also developing ColoAd1, a unique oncolytic virus developed using the evolutionary principle of natural selection to generate a virus with optimal anti-cancer properties. ColoAd1 is an extremely potent anti-cancer therapeutic with high selectivity for killing cancer cells but which shows little or no activity on normal tissue. The initial indications for the phase I/II clinical studies with ColoAd1 will be in metastatic colorectal cancer and primary hepatic cellular carcinoma.

The PsiOxus research pipeline also includes the vaccine platform PolySTAR, which combines recombinant viral vectors with polymers to shield them from the immune system, and the adjuvant and immunotherapeutic platform PolyMAP, which combines polymers with synthetic adjuvants to significantly enhance the effectiveness of vaccines.

In conjunction with the merger, PsiOxus completed a £3.6 million ($5.8 million) financing with the participation of all major investors of both predecessor companies, including Imperial Innovations, Invesco Perpetual, and the Mercia Fund. Hybrid directors Mark Payton (Mercia Fund) and Phil L'Huillier (Cancer Research Technology, Ltd.) join the PsiOxus board, together with Charles Swingland as an independent director. Proceeds from the financing will be used to advance MT-102 and ColoAd1 through phase I and II clinical development, and to develop new drug candidates derived from the PsiOxus platform technologies. The major shareholders of PsiOxus include Imperial Innovations, Invesco Perpetual, Mercia Fund, Cancer Research Technology and the University of Birmingham.

Dr Michael Moore, Chairman of PsiOxus commented:

"Through this combination, under the accomplished leadership of our Chief Executive John Beadle, we have brought together all of the key elements for a successful therapeutic development company, including talented teams with world-leading scientists, complementary technology platforms and experienced investors. As a combined entity, we have the clinical trials expertise among our scientific founders to develop promising new therapeutics to treat cancer and other serious diseases. We now look forward to advancing this product pipeline through the clinical stages ahead."

Susan Searle, Imperial Innovations Chief Executive, said:

"PsiOxus Therapeutics represents a rare opportunity to combine extensive clinical trials experience, world-class science and emerging technologies under a single, unified management team. We are pleased to be able to provide the team with the support and finances needed to expedite the clinical stage programmes and the research platforms toward commercialization."

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment
Post

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy