Ibuprofen may protect against development of Parkinson's disease

Mar 2 2011

New research suggests that ibuprofen may offer protection against developing Parkinson's disease, according to one of the largest studies to date investigating the possible benefits of the over-the-counter drug on the disease. The study is published in the March 2, 2011, online issue of Neurology®, the medical journal of the American Academy of Neurology.

Parkinson's disease is a brain disorder that causes tremors and difficulty with movement and walking. It affects about one million people in the United States.

"Our results show that ibuprofen may protect the brain in ways that other nonsteroidal anti-inflammatory drugs (NSAIDS) and analgesics, such as aspirin or acetaminophen, cannot," said Xiang Gao, MD, PhD, with Harvard School of Public Health, Brigham and Women's Hospital and Harvard Medical School in Boston.

For the study, researchers analyzed data taken from 98,892 female nurses and 37,305 male health professionals. Participants reported their use of ibuprofen and other NSAIDS. Taking ibuprofen two or more times per week was considered regular use. After six years, 291 were diagnosed with Parkinson's disease.

Scientists found that people who took ibuprofen regularly had a 38 percent lower risk of developing Parkinson's disease compared to those who did not take ibuprofen. After a larger analysis that combined several other studies on ibuprofen and other NSAID use, the researchers found that ibuprofen users had a 27 percent lower risk of developing the disease compared to non-users.

"One possibility as to why ibuprofen may have this effect against Parkinson's disease is that it may target a certain receptor in the brain called the peroxisome proliferator-activated receptor y (PPARy). Studies in animals have also suggested this effect," said Gao.

Editorial author James H. Bower, MD, MSc, with Mayo Clinic in Rochester, Minn., and a member of the American Academy of Neurology, said the study does not mean people should begin taking ibuprofen regularly to avoid developing Parkinson's disease. "Long-term ibuprofen use has a lengthy list of risks," he said. "However, the idea that ibuprofen may have these neuroprotective effects unique from other NSAIDS is cause for more research. Additionally, the use of ibuprofen may not be directly reducing the risk of Parkinson's. It may be related to some other unrecognized factor that is actually reducing the risk."

SOURCE American Academy of Neurology