CBIS initiates CS-TATI-1 GMP development plan

Aug 13 2012

Cannabis Science (CBIS), a pioneering U.S. Biotech Company developing pharmaceutical to meet global public health challenges is pleased to announce the initiation of GMP development plan for CS-TATI-1 with the initial production of CS-TATI-1 to be performed in Colorado under C-GMP conditions evaluated by the FDA for initial human studies to treat HIV associated Kaposi Sarcoma.

“Our analysis of utilizing an endosome based transdermal delivery of CS-TATI-1 in our initial studies will be optimal for addressing regulatory compliance concerns and meet the need of patients who are in need of effective localized delivery of the clinical activity of Cannabis Science's flagship therapeutic agent”

CBIS CS-TATI-1 is a preclinical development program intended to address the presentation of KSHV transactivation by HIV TAT. The codependent relation of the TAT's expression at the HIV LTR and the upregulation of Nf-KB dependent expression of Kaposi Sarcoma is well defined in peer reviewed publications.

Kaposi Sarcoma is a type of cancerous tumor of connective tissue. Kaposi Sarcoma produces nodules or patches that can affect the skin, mouth, nose, eye, lungs, liver, stomach, intestine, lymph nodes, and various other sites. Kaposi Sarcoma affected approximately one-third of all AIDS patients in resource poor settings on a global scale were the efforts of the global fund for AIDS, TB, and Malaria and the Presidents Emergency Program for AIDS relief is focused. Instances of Kaposi Sarcoma are also on the rise in drug resistant patient populations in the United States and Europe. Other countries, particularly those in Africa, have a high rate of Kaposi Sarcoma. Also, about twenty percent of AIDS patients who do not take antiretroviral drugs have Kaposi Sarcoma.

"Our analysis of utilizing an endosome based transdermal delivery of CS-TATI-1 in our initial studies will be optimal for addressing regulatory compliance concerns and meet the need of patients who are in need of effective localized delivery of the clinical activity of Cannabis Science's flagship therapeutic agent," said Dr Robert Melamede, President & CEO of Cannabis Science Inc.

Initial vendor bid solicitation is being managed by corporate leadership as CBIS develops an executive team to facilitate scale of production over the next quarter, as CBIS pursues federal sponsorship of initial studies in publically funded clinical trial programs.

Source Cannabis Science, Inc.