XenoPort's Arbaclofen placarbil fails to meet co-primary endpoints in Phase 3 clinical trial

May 20 2013

XenoPort, Inc. (Nasdaq: XNPT) announced today top-line results from its pivotal Phase 3 clinical trial of arbaclofen placarbil (AP) for the treatment of patients with spasticity due to multiple sclerosis (MS). The trial was unsuccessful in demonstrating that AP provided statistically significant improvement relative to placebo in the co-primary endpoints of the study.

Ronald W. Barrett, Ph.D., chief executive officer of XenoPort, stated, "We are obviously disappointed that the co-primary efficacy endpoints were not met. Based on the results of the study, we have decided to terminate further investment in this program. We will be working diligently to shut down all activities related to AP development, and plan to provide an update in the future on the impact of these expected savings on our cash burn guidance. We remain committed to allocating our resources to build value through the focused commercialization of Horizant and advancing the development of our novel fumarate product candidate, XP23829."

SOURCE XenoPort, Inc.