Graphene may lead to new applications in the diagnosis and treatment of neurological diseases

Wolters Kluwer HealthApr 26 2014

Graphene has possible uses in brain cancer treatment, neuroregeneration, functional neurosurgery, and more

The development of graphene-a highly advanced metamaterial with many unique and varied properties-may lead to exciting new applications in the diagnosis and treatment of neurological diseases, according to a report in the May issue of Neurosurgery, official journal of the Congress of Neurological Surgeons. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

Tobias A. Mattei, MD, of Invision Health/Brain & Spine Center - Buffalo, New York and Azeem A. Rehman, BS, of The University of Illinois College of Medicine at Peoria present a "primer" on the development of graphene-based metamaterials that may lead to new advances in several areas of neurosurgery. Mattei and Rehman write, "As a surgical specialty that heavily relies on technological innovations, it is expected that neurosurgery will significantly benefit from several graphene-based technological developments in the next decades."

Graphene Has 'Extremely Remarkable' Properties -

An artificially engineered "metamaterial"-with properties not typically found in nature-graphene is composed of a single layer of carbon atoms in a "honeycomb lattice" pattern. The developers of graphene were awarded the Nobel Prize in Physics in 2010; massive resources are being invested in its further research and development.

Graphene has a number of "extremely remarkable" properties that make it unlike any other material. It combines the greatest mechanical strength ever measured in any material- natural or artificial-with very light weight and high elasticity. Graphene also has unique optical and photothermal properties which, among other things, allow it to release energy in the form of heat in response to light input.

In addition, graphene has very high electrical conductivity, as well as a high surface area allowing "efficient bioconjugation" with common biomolecules. A few years ago, graphene was one of the most expensive materials on Earth. However, as industrial production increases, it is dropping rapidly in price.

Graphene is being developed for use in a wide range of technologies, such as flexible liquid crystal displays and electronic devices, new types of integrated electric circuits, and lithium-ion microbatteries-to name just a few. It also has great promise for use in various types of biomedical devices, several of which are relevant to conditions treated by neurosurgeons.

-With Many Promising Applications in Neurosurgery

Mattei and Rehman discuss some of the frontline scientific research being done to explore the capabilities and potential uses of graphene. As development continues, graphene-based metamaterials could contribute to advances in several areas of neurosurgery, including:

• Cancer Treatment. Graphene nanoparticles may play a role in tumor-targeted imaging, as well as possible new therapeutic approaches involving photothermal or alternating electrical field stimulation therapies.

• Intensive Care Unit Monitoring. New electrochemical and optical biosensors may provide new approaches to neurologic monitoring in patients with stroke or traumatic brain injury.

• Neuroregeneration. Graphene materials may be used in new strategies to promote regeneration of nervous system tissues-for example, graphene-coated scaffolds to stimulate growth of injured peripheral nerves.

• Functional Neurosurgery. Improved electrophysiological monitoring systems may help in performing precisely targeted brain surgeries in patients with conditions such as epilepsy and movement disorders.

• Spinal Surgery. High-resistance graphene-based hardware may represent the next generation in instrumentation for spinal surgery.

However, much work remains before any of these advances become reality. While graphene has been shown to be biocompatible, more basic research is needed to examine the long-term biological effects of graphene implants and to answer other important clinical questions. Mattei and Rehman conclude, "Increased awareness of the ongoing frontline research on graphene may enable the neurosurgical community to properly take advantage of the technological applications such a new metamaterial may offer to experimental and clinical neurosurgery in the near future."