Real-time surgical guidance study to evaluate TriVersa NanoMate with LESA capability from Advion

Advion, Inc. announces that is its TriVersa NanoMate with liquid extraction surface analysis (LESA) capability will be evaluated as part of a study at Brigham and Women’s Hospital.

When coupled to a mass spectrometer, the TriVersa NanoMate with LESA capability allows for automated and direct sample analysis from samples with minimal sample preparation. The user can select tissue samples around the interest area, and get real-time mass spectral data.

Dr. Nathalie Agar, Director of the Surgical Molecular Imaging Laboratory in the Department of Neurosurgery at BWH, will work with tissue preparations for biomarker analysis to guide real-time surgical margin decisions in the operating room with a comparison to alternative modern techniques as well as traditional pathology. The purpose of the study is to determine novel markers for cancer tissue, detect them using LESA and mass spectrometry, and then guide precise and accurate surgery marginal incision start and stop points. If successful, this could increase treatment success, decrease residual cancer presence and minimize unnecessary removal of healthy tissue. 

According to Advion Chief Scientific Officer, Jack Henion, PhD,

This is an exciting aspect of translational research for cancer biomarkers that potentially has immediate benefit for patients undergoing cancer surgery. In the intended workflow from ‘bench-to-bedside’ (or more accurately from ‘bench-to-operation room’) a surgical decision is guided not only by standard procedures but additionally by mass spectrometry data from tissue samples obtained in real-time during the procedure.

Pilot experiments are now underway with an initial publication targeted for early 2015.

About Advion, Inc.

Advion develops, manufactures and globally supports mass spectrometers, chip-based ion sources, microfluidic flow chemistry systems and consumables for life science and related industries. We seek to enhance analysis performance and workflows. Using our deep scientific and engineering knowledge of mass spectrometry and microfludics, we leverage our passionate employees’ commitment to create quality, flexible and fit-for-purpose solutions. More about Advion, Inc. can be found on our website, www.advion.com.