University of Pennsylvania cancer and HIV expert Carl June, MD, has been named one of two recipients of the 2015 Paul Ehrlich and Ludwig Darmstaedter Prize for his outstanding work in cancer immunotherapy. Since 1952, the Paul Ehrlich and Ludwig Darmstaedter Prize has been awarded to scientists who have made great advancements in the fields in which Paul Ehrlich worked, in particular immunology, cancer research, microbiology, and chemotherapy. The prize is presented each year on March 14, the anniversary of Paul Erhlich's birthday, in Frankfurt, Germany.
June is the Richard W. Vague Professor in Immunotherapy in the department of Pathology and Laboratory Medicine in the Perelman School of Medicine at the University of Pennsylvania and director of Translational Research in Penn's Abramson Cancer Center.
He is widely recognized as leader of the team responsible for the first successful and sustained demonstration of the use of CAR T cell therapy, an investigational approach in which a patient's cells are removed through an apheresis process similar to dialysis and modified in Penn's cell and vaccine production facility. Scientists there reprogram the patients' T cells through a gene modification technique using a viral vector that trains them to recognize specific types of cancer cells. The modified cells - known as chimeric antigen receptor (CAR) T cells - are then infused back into the patient's body, where they multiply, hunt and attack tumor cells.
The latest results of clinical trials of more than 125 patients showed a response rate of 90 percent among pediatric and adult acute lymphoblastic leukemia patients. Among patients with chronic lymphocytic leukemia, the earliest group the research team began clinical trials with, in 2010, about 50 percent of patients respond to the therapy, and remissions among some of the first patients treated with the approach now exceed four and a half years. Early results in studies of patients with lymphoma and myeloma are also promising, and clinical trials are now underway to test this approach in patients with solid tumors.
June has published more than 350 manuscripts and has received numerous prizes and honors, including election to the Institute of Medicine in 2012, the William B. Coley award, the Karl Landsteiner Memorial Award from the AABB, the Richard V. Smalley Memorial Award from the Society for Immunotherapy of Cancer, the Philadelphia Award, and the Hamdan Award for Medical Research Excellence. In 2014 he was elected to the American Academy of Arts and Sciences.
June is a graduate of the U.S. Naval Academy, and Baylor College of Medicine in Houston. He received graduate training in Immunology and malaria at the World Health Organization in Geneva, Switzerland, and post-doctoral training in transplantation biology at the Fred Hutchinson Cancer Research Center.
James P. Allison, PhD, a professor at the University of Texas MD Anderson Cancer Center, also received this year's Paul Ehrlich and Ludwig Darmstaedter Prize.
Study uncovers key mechanism behind HIV latency