Univercell-Biosolutions opens center of expertise with industrial, standardized approach to hiPSC production

Jun 25 2015

The center of expertise is the first in the world to offer quality control and process management applied to a large panel of standardized products based on the Pluri-one^® platform

Univercell-Biosolutions, a leading provider of human induced pluripotent stem cells (hiPSC) and hiPS derived product cells for drug discovery, today announces the opening of a center of expertise with an industrial and standardized approach to hiPSC production.

Based on its hiPSC Pluri-one^® platform, the company can now offer a wide range of standardized products, services and technology transfer activities. The center of expertise is based in Toulouse at the Pierre Potier Center. It has eight members of staff. The center received a total investment of €3.3M with the support of French state-backed investor BPIFrance and the metropolitan district of Toulouse, who have been supporting the project since 2012.

Univercell-Biosolutions has developed a proprietary industrialized platform and processes that meet high-quality industry standards. The technology has been validated by strict quality control tests that certify a high reproducibility and process stability from batch to batch. Furthermore, Univercell-Biosolutions is the first company to provide an industrial approach to hiPSC production taking into account the requirements of differentiation protocols.

hiPSC is an important raw material that has to be managed under strict quality controls to provide a reliable resource. It is commonly used in medical research for disease modeling, drug development, organ synthesis and tissue repair. These stem cells also have potential in regenerative and transplantation medicine.

The two main groups using hiPSc are:

• Those using the cells as an initial resource in medical research (for the production of neuron, liver, cardiomyocytes…)
• Those working on cell reprogramming who often do not take into account the application potential of their hiPSCs

To bridge the communication gap between these groups, Univercell-Biosolutions’ center of expertise offers a large panel of standardized products based on the Pluri-one^® platform. These solutions are specifically designed to integrate end-user requirements and objectives. The Pluri-one^® portfolio cell lines have been designed to fit the different culture systems and to integrate the differentiation potential of iPSC.

To fit each differentiation protocol, the Univercell-Biosolutions team has developed four hiPSC culture systems:

• Pluri-one^® MEF-C: Clumps of hiPSC adapted to mitomycin MEF culture
• Pluri-one^® MEF-CO: Clumps of hiPSC adapted to enzymatic passage and mitomycin MEF culture
• Pluri-one^® DM-C: Clumps of hiPSC adapted to qualified matrix culture
• Pluri-one^® DM-SC: Single cells of hiPSC adapted to qualified matrix culture

Univercell-Biosolutions’ adaptable platform is able to provide clients with technology transfer, adjusting to specific in-house needs. The company can also assist with platform set up and provide staff with training and regulation of protocols.

“We have decided to define our products and solutions based on customer application requirements and not just on the hiPSC cell pluripotent status,” said Guillaume Costecalde, CEO at Univercell-Biosolutions. “Our center of expertise is now able to provide all our customers with the expertise and the hiPSC cell lines they need to successfully take advantage of this revolution.”

“I wanted to apply my experience in the clinical production of adult stem cells to the induced pluripotent stem cells space. This relatively new industry is not familiar with the strict and proven industrial processes,” said Philippe Bourin, CSO at Univercell-Biosolutions. “With our quality control tests, adaptability and reliability, we have gone one step further in an industrialized hiPSC market.”

Source: http://www.univercell-biosolutions.com/