Noradrenaline exerts positive effects on vision by binding to b-adrenergic receptors

Feb 9 2017

Noradrenaline is a neuromodulator secreted in the brain depending on behavioral context and physiological states of animal, influencing a wide range of physiological functions by modulating brain activity. It may be best known as a hormone to regulate heart rate and blood flow, and many drugs, such as well-known beta blockers, target its effects. It also modulates the visual system.

"Noradrenaline administration modulates the primary visual cortex (V1)", says Osaka University Associate Professor Satoshi Shimegi. "It changes the spatial sensitivity of this region."

Understanding how noradrenaline functions in the brain is expected to give new insights on how the brain processes spatial information, which has important implications on patient care and machine learning.

Noradrenaline exerts its effects by binding to adrenergic receptors. Beta blockers target b-adrenergic receptors, but there are also exist a-adrenergic receptors, for which there exists alpha blockers. The binding of noradrenaline to its receptors leads to a reduction of spontaneous neural activity in V1, but studies on different animals have been inconclusive about which receptors are primarily responsible for this effect.

In a new set of experiments, the Shimegi lab observed the effects of noradrenaline on the vision of free-moving rats. "We wanted to observe behaving animals, because this is a better representation of nature," explained Ryo Mizuyama, first author of the study, which can be read in PLOS ONE.

The rats were subjected to one of two different inhibitors of a-adrenergic receptors or one inhibitor of b-adrenergic receptors. Of the three, only the b-adrenergic receptor inhibitor, propranolol hydrochloride, had an effect on vision performance.

"Contrast sensitivity was suppressed", said Mizuyama, who further added that, "contrast sensitivity defines one's ability to distinguish objects at different light and dark contrasts."

Interestingly, however, the effect on contrast sensitivity was found only for a specific range of spatial frequencies.

"The contrast sensitivity at optimal spatial frequencies was suppressed by propranolol hydrochloride," observed Shimegi. "This result suggests that only neurons sensitive to specific spatial frequencies are affected by the inhibitor. Therefore, noradrenaline could improve vision by targeting a very small subgroup of neurons or neural circuits."