Study provides insights into how HCMV infection causes birth defects

May 15 2017

Fresh insights into how a common virus replicates could pave the way for new therapies to stop its spread.

Scientists have discovered a key molecule linked to Human Cytomegalovirus (HCMV) infection, which is harmless for healthy people but can cause miscarriage and birth defects during pregnancy.

Tests on infected cells found that blocking the molecule with a chemical inhibitor stops the virus from multiplying.

The molecule - called VCP - is a component of the infected cell rather than a substance produced by the virus itself.

Researchers at the University of Edinburgh's Roslin Institute found the virus is dependent on VCP to replicate its genetic material and multiply.

Chemicals that block the activity of VCP are 10 times more powerful at stopping the virus than existing medications that target HCMV directly, the study found.

By targeting the affected cells instead of the virus, the approach could also cut the chances of the virus becoming resistant to the therapy, researchers say.

Drugs that target VCP are already being developed as potential therapies for cancer. Studies to check whether the drugs are safe for use will be needed before they could be tested as a therapy for the virus.

HCMV is extremely common. It infects at least 30 percent of the population in the developed world and up to 100 percent of people in developing countries.

It can be life-threatening for people with a weakened immune system, such as transplant recipients and people infected with HIV.

Infection during pregnancy can lead to hearing loss and intellectual disabilities in unborn babies.

The study is published in the journal PLOS Pathogens.

Dr Finn Grey, a Senior Research Fellow at the University of Edinburgh's Roslin Institute, said: "Human Cytomegalovirus infection is an important human disease. By gaining a better understanding of how the virus works, we can develop improved antiviral drugs. While more work is required, this study shows the potential of such approaches."