An international team of researchers led by scientists at the Child Mind Institute has released the first open-source data sets of non-human primate brain imaging. In a new study, An Open Resource for Non-human Primate Imaging published in the journal Neuron, the researchers present details about the rationale, design, and procedures for the PRIMatE Data Exchange (PRIME-DE) consortium, an open science resource for the neuroimaging community that aims to aggregate and share anatomical, functional and diffusion MRI data sets from laboratories around the world. The goal is to accelerate the development of a map of the neural connections in the non-human primate brain -- and, ultimately, the human brain -- in an effort to develop biomarkers for mental health disorders and other brain disorders and diseases.
The consortium, led by Michael P. Milham, MD, PhD, the Phyllis Green and Randolph Cowen Scholar and vice president of research at the Child Mind Institute alongside Charles Schroeder (Columbia University) and Daniel Margulies (ICM and Max Planck Institute), presents details of 25 independent data collections aggregated across 22 sites. The study also outlines the unique pitfalls and challenges that should be considered in the analysis of the non-human primate MRI datasets, including providing automated quality assessment of the contributed datasets.
"This is a rapidly growing and extremely promising area of neuroscience research that suffers from a lack of data," said Dr. Milham. "The PRIMatE Data Exchange is an effort to encourage and enable the independent collection and sharing of brain imaging data through the International Neuroimaging Data-Sharing Initiative (INDI). The ultimate goal is to accelerate research that improves our understanding of how the human brain works and translates that understanding into enhanced methods for the diagnosis and treatment of a range of brain disorders."
Disrupting the circadian rhythm of glioblastoma slows tumor growth, study says