Themis announced today that it has entered into a license agreement with Max-Planck-Innovation GmbH, the technology transfer agency of the Max Planck Society in Germany, granting it exclusive worldwide license to develop, manufacture and commercialize therapies based on an oncolytic measles virus platform that was jointly developed by the Eberhard-Karls-University Tübingen and the Max Planck Institute for Biochemistry. Financial terms of the agreement were not disclosed.
"This is a transformative step for the company and will broaden our immunomodulation platform into oncology. It also greatly complements our existing patent portfolio around the measles vector technology for infectious diseases," commented Erich Tauber, CEO and founder of Themis. "We believe the long standing expertise of Prof. Ulrich Lauer's virotherapy research group at the University Tübingen in advanced oncolytic approaches together with our measles virus product development capabilities provide a strong foundation to rapidly develop differentiated immuno-oncology therapeutics."
The licensed technology is a modified measles virus based on the viral genome sequence of the established measles vaccine strain, which has been used to immunize billions of people worldwide. The measles virus itself has innate anti-cancer properties, for example, mediating tumor cell lysis, T cell activation and specific tumor cell targeting. Furthermore, it can also be engineered to include a tumor killing payload, making it a major building block for an effective oncolytic virus immunotherapy.
Themis established a robust cGMP manufacturing process for its measles vector technology and built a broad pipeline with both proprietary and partnered infectious disease vaccine candidates. The lead program in Chikungunya is anticipated to enter Phase 3 development in the near- to medium-term. Themis believes that today's licensing deal with Max-Planck-Innovation GmbH will further expand its innovative technology platform to include novel oncolytic virus-based immunotherapy applications.
Study reveals how cancer cells evade chemotherapy in low-glucose environments