Research may help explain why migraine is more common in women than men

Low doses of a peptide known for decades to be involved in migraine trigger pain responses in female but not male rodents, according to a new research published in JNeurosci. This finding may help explain why migraine is more common in women than men.

Despite its well-established role in migraine, it is unclear where in the body calcitonin gene-related peptide (CGRP) contributes to the headache. Whether sex differences exist in the neurobiology of this female-biased disorder is also unknown because previous investigations of CGRP and migraine have typically only used male animals.

Gregory Dussor and colleagues at the University of Texas at Dallas and the UT Health Science Center addressed these gaps by studying rat and mouse migraine models that include animals of both sexes. The researchers found injecting low doses of CGRP into the dura mater – the protective outer layer between the skull and the brain – produced headache symptoms only in females. They observed a similar effect when CGRP was injected into the female animals’ paw.

Citations

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Society for Neuroscience. (2019, June 20). Research may help explain why migraine is more common in women than men. News-Medical. Retrieved on November 21, 2024 from https://www.news-medical.net/news/20190409/Research-may-help-explain-why-migraine-is-more-common-in-women-than-men.aspx.

  • MLA

    Society for Neuroscience. "Research may help explain why migraine is more common in women than men". News-Medical. 21 November 2024. <https://www.news-medical.net/news/20190409/Research-may-help-explain-why-migraine-is-more-common-in-women-than-men.aspx>.

  • Chicago

    Society for Neuroscience. "Research may help explain why migraine is more common in women than men". News-Medical. https://www.news-medical.net/news/20190409/Research-may-help-explain-why-migraine-is-more-common-in-women-than-men.aspx. (accessed November 21, 2024).

  • Harvard

    Society for Neuroscience. 2019. Research may help explain why migraine is more common in women than men. News-Medical, viewed 21 November 2024, https://www.news-medical.net/news/20190409/Research-may-help-explain-why-migraine-is-more-common-in-women-than-men.aspx.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment
Post

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
High fat diet limits birth and development of new neurons in female mice