Advanced paternal age associated with risk of neurodevelopmental disorders in children

It is no secret that genetic factors play a role in determining whether children have neurodevelopmental disorders. Maternal exposure to drugs and viral or bacterial illnesses can be detrimental too.

However, a recent epidemiological survey of approximately 6 million people worldwide has revealed that advanced paternal age is associated with the development of neurodevelopmental disorders. In other words, the older the parent, the increased risk a child has of developing disorders such as autism, ADHD and other learning disabilities.

A research team from the Department of Developmental Neuroscience at the Tohoku University Graduate School of Medicine has revealed further details about this phenomenon with their recent publication in PLOS ONE.

The research team, led by doctoral student Misako Tatehana and Professor Noriko Osumi, performed immunohistochemical analysis of the testis in three-month-old mice before performing the same analysis on mice aged 12 months or older.

Tatehana and her team analyzed histone proteins during the 12-step spermatogenesis process. Histone proteins undergo chemical modifications during spermatogenesis, thereby affecting gene expression. More specifically, the team looked at the seven methylations and one acetylation.

They cataloged these as epigenetic markers -- modifications that affect the expression of the gene without changing the DNA base sequence of the genome itself.

Comparisons of the markers between the younger and older mice using imaging quantification techniques revealed that the latter had higher amounts of the modified histone protein, H3K79me3. A previous study by Professor Osumi found a correlation between the amount of H3K79me3 in sperm and abnormal speech communication in pups, making it a predictive marker of neural-developmental disorders.

This new finding signals that paternal aging potentially affects neurodevelopment in humans. Further research on the matter hopes to develop greater diagnostic methods for disorders stemming from the risk of advanced paternal age.

Source:
Journal reference:

Tatehana, M., et al. (2020) Comprehensive histochemical profiles of histone modification in male germline cells during meiosis and spermiogenesis: Comparison of young and aged testes in mice. PLOS ONE. doi.org/10.1371/journal.pone.0230930.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment
Post

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
New Johns Hopkins study shows digital tools help prevent obesity in high-risk young children