Study: Patients should be assessed for frailty before considering multiple surgeries

Reviewed by Emily Henderson, B.Sc.Feb 18 2021

Patients should be assessed for frailty before having many types of surgery, even if the surgery is considered low risk, a review of two national patient databases shows.

Frailty is a clinical syndrome marked by slow walking speed, weak grip, poor balance, exhaustion and low physical activity. It is an important risk factor for death after surgery, although the association between frailty and mortality across surgical specialties is not well understood.

The study, conducted by faculty at multiple institutions including The University of Texas Health Science Center at San Antonio (UT Health San Antonio), mined patient data from the Veterans Affairs (VA) Surgical Quality Improvement Program and the American College of Surgeons (ACS) National Surgical Quality Improvement Program.

"In previous research, we introduced the concept of an Operative Stress Score to assess the impact of frailty on mortality after surgery," said Paula K. Shireman, MD, MS, MBA, professor of surgery at UT Health San Antonio. She is a vascular surgeon in the university's Joe R. and Teresa Lozano Long School of Medicine and the South Texas Veterans Health Care System.

In that first study, which examined only VA data, we showed that even patients undergoing low-risk procedures had very high post-operative mortality."

Paula K. Shireman, MD, MS, MBA, Professor, Surgery, University of Texas Health Science, San Antonio

The question remained: Because frailty screening takes effort and clinics are busy, are there specialties that shouldn't do it because they perform mainly low-risk procedures in patients who are at low risk? In these specialties, does the effort of screening outweigh the benefit?

The newest research, published in JAMA Surgery, assigned Operative Stress Scores (OSS) to cases performed in nine noncardiac specialties including vascular surgery, orthopaedic surgery, neurosurgery, gynecologic surgery, urologic surgery, and ear, nose and throat surgery.

"This time, instead of looking at all cases broadly, we characterized different specialties as high risk or low risk," Dr. Shireman said. "For example, most of the procedures done by urologic surgeons are relatively low risk. Vascular and thoracic surgeons, on the other hand, perform many high-risk procedures."

Operative Stress Scores categorized procedures as low (1-2), moderate (3) and high (4-5) stress. Specialties were categorized by case mix as predominantly low intensity, moderate intensity or high intensity. "Basically, did they do more OSS-1s or did they do more OSS-5s?" Dr. Shireman said.

The study examined 30-day postoperative mortality in the VA case records and 30-day and 180-day mortality after surgery in the ACS registry. 2.3 million patient records are in the American College of Surgeons database and 426,000 in the VA database. 56% of the patients in the ACS registry were women, while 93% of the patients in the VA registry were men. All patients were 18 or older.

The key finding: "Frailty was a consistent, independent risk factor for 30- and 180-day mortality across all specialties," the authors wrote.

"Based upon all of this, the results showed that frailty is prevalent enough that it should be screened in all different surgical specialties, regardless of the case mix," Dr. Shireman said.

Cardiac specialties were not included. The VA has a separate registry for cardiac procedures versus all other surgeries, Dr. Shireman said. The researchers used the all-other-surgeries VA registry.