Tuberculosis is a serious infectious disease, which is caused by the Mycobacterium tuberculosis, generally it affects the lungs. Tuberculosis is spread from one person to another through microscopic droplets released into the air, it can happen through coughs, speaks, sneezes, spits, laughs from the active tuberculosis patient.
According to the recent survey on tuberculosis by world Health Organization, in 2018, 10 million people fell ill with TB, and 1.5 million died from the disease. These numbers are alarming the need for more efforts to fight against the tuberculosis.
The book entitled "In-Silico and In-Vitro Approaches to Screen the Anti-tuberculosis Activity of Benzothiazole Analogs" comprises of six chapters, with extensive literature documentation on the benzothiazole analogs and corresponding structure activity relations, further authors enumerated the in-vitro and in-silico methodology for the screening the benzothiazole molecules to the anti-TB regime.
Further various chapters explained the synthesis of the different types of the benzothiazole scaffold moiety and their tuberculosis activities with neat descriptions of the methodology. Additionally, each chapter includes the synthetic schemes, with mechanism for the benzothiazole derivatives.
This book, therefore, is a quick reference on TB diseases, methods of in-silico and in-vitro screening of anti-TB drugs and the importance of the benzothiazole in TB treatment regimens. The book is suitable for readers, researchers and post graduate students who are interested in general tuberculosis drug design, screening and discovery, as well as the application of benzothiazole as an anti-TB drug.
Novel anti-tuberculosis compound targets bacterial membrane protein