Oxford's Ebola vaccine candidate manufactured and shipped to Uganda in just 80 days

Reviewed by Emily Henderson, B.Sc.Jan 5 2023

Oxford's Ebola vaccine candidate has been shipped to Uganda, just 80 days after WHO declared a Sudan ebolavirus outbreak, having been manufactured by its partner the Serum Institute of India and working in close partnership with WHO.

Following presentation of key data to the WHO generated in Oxford by Prof Lambe's team, it was announced on 17th November that the vaccine had been recommended for inclusion in a ring vaccination trial to combat a Sudan ebolavirus outbreak in Uganda. The WHO working in partnership with the Ugandan government and Ministry of Health have enabled the ring vaccination trial as part of a multi-faceted effort to curb the outbreak and save lives.

The Oxford team led by Prof Lambe have been working on the vaccine for some time, including ongoing clinical trials in Oxford and Tanzania; manufacture scale-up was led by the Serum Institute and supported by Prof Sandy Douglas, of the Jenner Institute. This research was funded by the Department of Health and Social Care (DHSC). SII (Serum Institute of India), who also partnered with the University to manufacture the Covid vaccine, produced 40,000 doses for the trial in just a few short weeks.

This is a phenomenal feat by all involved, especially our partners Serum Institute. This exceptional partnership has demonstrated yet again the importance of academics working with large-scale manufacturers to rapidly pivot and respond to outbreaks, and the importance of working with and having the full support of WHO. Importantly, the speed at which we responded, gives real hope to achieving the 100 day mission and tackle deadly diseases of global impact."

Teresa Lambe OBE, Professor of Vaccinology and Immunology, Oxford Vaccine Group

A number of organizations, including government bodies have embarked upon an ambitious plan to dramatically reduce or even eliminate the future risk of pandemics and epidemics. Part of the plan is to compress the time taken to develop safe, effective, globally accessible vaccines against new threats to just 100 days. Achieving this '100 Days Mission' would give the world a fighting chance of containing a future outbreak before it spreads to become a global pandemic.

Adar Poonawalla, CEO of Serum Institute of India, shared, "To combat the widespread outbreak of the Sudan ebolavirus in Uganda, it is important to prioritize immunization. The 40,000 vaccine doses manufactured in record time is a remarkable milestone in our long-standing association with Oxford University. I would also like to thank the Government of India for their constant support in enabling us to help people worldwide through effective, and accessible health interventions."