Malnutrition in heart failure patients associated with diminished GDMT prescription rates

Announcing a new article publication for Cardiovascular Innovations and Applications journal. This study was aimed at identifying crucial gaps in guideline-directed medical therapy (GDMT) application among malnourished patients at Beijing Anzhen Hospital. Data from patients with heart failure (HF) admitted between January 1, 2018, and April 30, 2023, were analyzed.

Malnutrition was assessed with Controlling Nutritional Status (CONUT) and Geriatric Nutritional Risk Index (GNRI) scores. GDMT regimens were defined as follows. The triple-therapy regimen included β-blockers, renin-angiotensin system inhibitors (RASIs), and mineralocorticoid receptor antagonists (MRAs). Dose-optimized triple therapy consisted of β-blockers, RASIs, and MRAs, each at ≥50% of the target doses. Dose-optimized double therapy was defined as any two of the three therapies administered at ≥50% of the target doses. Multivariable logistic regression analyses were conducted to examine the relationship between malnutrition and GDMT prescription.

Among 1397 patients, malnutrition was associated with lower prescription rates of triple-therapy (CONUT: OR 0.70, 95% CI 0.54-0.91; GNRI: OR 0.63, 95% CI 0.43-0.92), dose-optimized triple-therapy (CONUT: OR 0.59, 95% CI 0.36-0.97; GNRI: OR 0.35, 95% CI 0.11-1.17), and dose-optimized double-therapy (CONUT: OR 0.65, 95% CI 0.50-0.86; GNRI: OR 0.56, 95% CI 0.35-0.89) than observed in patients with normal nutrition after multivariable adjustment.

Malnutrition in hospitalized patients with HF with LVEF <50% was associated with diminished prescription rates of GDMT at discharge.

Source:
Journal reference:

Liu, X., et al. (2025). Association Between Malnutrition and Guideline-Directed Medical Therapy Utilization at Discharge in Hospitalized Patients with Heart Failure. Cardiovascular Innovations and Applications. doi.org/10.15212/cvia.2025.0005.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment
Post

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Groundbreaking discovery in cardiac regeneration offers new hope for heart failure treatment