Exploring the relationship between testosterone and men's health

The review article titled"Testosterone and men's health: An in-depth exploration of their relationship", was published on February 18, 2025 in UroPrecision.

Testosterone is a steroid hormone that holds a central position in male health, influencing numerous physiological processes throughout a man's life. Primarily secreted by the testes, with smaller contributions from the adrenal glands, it is the main androgen responsible for male-specific characteristics.

During fetal development, testosterone drives sexual differentiation, determining the male reproductive system's formation. As boys reach puberty, it triggers the development of secondary sexual traits such as facial and body hair growth, a deeper voice, and increased muscle mass. These changes are not only physical but also have psychological implications, shaping a man's self-identity.

In adulthood, testosterone continues to play a crucial role in maintaining health. It is essential for male reproductive function, stimulating sperm production in the testes. Additionally, it supports libido and erectile function. Low testosterone levels are often associated with sexual dysfunction, including decreased sexual desire and erectile problems, which can significantly impact a man's quality of life and relationships.

Beyond the reproductive system, testosterone has far-reaching effects. It helps maintain muscle mass and strength. By promoting protein synthesis, it enables muscles to grow and repair, contributing to physical performance and overall mobility. Testosterone also plays a vital role in bone health. It helps preserve bone density, reducing the risk of osteoporosis and fractures, especially as men age.

Moreover, testosterone influences metabolism. It affects fat distribution, with low levels often leading to increased abdominal fat. This is significant because abdominal obesity is linked to various health issues, such as metabolic syndrome, diabetes, and cardiovascular diseases. Adequate testosterone levels can help regulate cholesterol levels and improve insulin sensitivity, reducing the risk of these chronic conditions.

However, abnormal testosterone levels can pose problems. Hypogonadism, characterized by low testosterone, can be caused by issues in the testes, hypothalamus, or pituitary gland. It is more common in older men and those with certain health conditions like obesity and diabetes. On the other hand, hypergonadism, or excessive testosterone production, can result from tumors or genetic disorders and may lead to symptoms like early puberty in boys, aggression, and infertility.

Precision medicine offers hope in managing testosterone-related disorders. By considering genetic, hormonal, and lifestyle factors, doctors can develop personalized treatment plans. Biomarkers are key in this process, allowing for more accurate diagnosis and treatment monitoring. For instance, measuring free testosterone, SHBG, and LH levels helps assess a man's androgen status.

Despite the progress in understanding testosterone, there are still challenges. Research on testosterone replacement therapy (TRT) has limitations, including small sample sizes and safety concerns related to cardiovascular risks and prostate health. Future studies are needed to fully understand testosterone's complex role in men's health and to develop more effective and safer treatment options. In conclusion, testosterone is a critical factor in men's health, and continued research is essential for optimizing male health and well-being.

Source:
Journal reference:

Yassin, A., et al. (2025). Testosterone and men’s health: An in‐depth exploration of their relationship. UroPrecision. doi.org/10.1002/uro2.115.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment
Post

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
The X factor: Decoding brain aging differences between men and women