1. Major problems with this study
    Erik Sass Erik Sass United States says:
    October 22, 2020 at 10:37 AM

    • Underpowered, with 1,483 healthcare workers enrolled versus total target 3,150
    • Used low dose of HCQ, 400 mg once or twice weekly
    • Study relied on symptom-based reporting and diagnosis due to limited availability of PCR testing, but
    failed to investigate other possible causes of symptoms
    • Irregular reporting characterized by wide variation in timing of matching symptoms and PCR tests (where
    available). Study counted PCR+ tests within 14 days before/after symptoms, but PCR- tests within just
    four days of symptoms. Results suggest symptoms-based diagnosis is highly inaccurate
    • Despite these shortcomings, study actually suggests positive effect with 28% relative risk reduction of
    infection by giving HCQ weekly for 6-8 weeks

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