1. N501Y mutation and STE90-C11
    Paul Wolf Paul Wolf United States says:
    December 27, 2020 at 5:02 AM

    This was written before the N501Y mutation started taking over the world.  Are you familiar with the molecular modeling work of Filip Fratev that suggests this mutation reduces the binding affinity to STE90-C11 by a factor of 160?  It is just a mathematical model without any experimental proof but may explain how this mutation has spread so rapidly - by evading an important antibody produced against it.  www.biorxiv.org/.../2020.12.23.424283v1

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