I like the way that the electronic cigarette was compared to the actual cigarette in this study. This is what needs to be done in all studies because the whole reason for using the ecigarette is to have a healthier alternative to smoking when one can not or will not quit.  A lot of other studies compare ecigarettes to nothing and that, of course does not accomplish anything. Tobacco harm reduction should be very important since we have all seen or heard of family members and friends dying of smoking but still continuing to smoke.